Description Usage Arguments Details

this function check the parameters required to calcul the sample size for nsurvival and ncoprimary functions. datacheck is a simple utility for carrying out parameter checks and reporting on problems or errors.

1 |

`design` |
Superiority=c(1,sided)[with sided=1 if 1-sided and 2 if 2-sided]; Non inferiority=c(2); Equivalence=c(3) |

`Survhyp` |
For Superiority=c(thyp,t,hype,Sc); for Non inferiority=c(thyp,t,hype,Sc,hypeA); for Equivalence=c(t,delta,Sc): parameters at time t if thyp=1 then hype is survival rate in experimental arm under the null hypothesis and hypeA is the survival rate in the experimental arm under the alternative hypothesis; if thyp=2 then hype is the hazard ratio under the null hypothesis and hypeA is the hazard ratio under the alternative hypothesis; Sc is the survival rate in the control arm; delta is the log hazard ratio equivalence margin. When endpoint is HRQoL, the survival rate is replaced by the rate of patients without the HRQoL deterioration. |

`pe` |
Proportion (ratio) of patients assigned to the experimental arm (with 0<pe<1) |

`alfa` |
Type I error, for Non inferiority, Equivalence and 1-sided superiority, alfa is a vector of length one. For 2-sided superiority, alfa is a vector to length two c(alpha.low, alpha.up). |

`beta` |
Probability of a type II error. |

`duraccrual` |
Accrual duration, expressed in number of days, months or years |

`durstudy` |
Study duration, expressed in number of days, months or years |

`look` |
The number interim analyses, c(1) for one final analysis; c(nb, bound, timing) for at least one interim analyses with bound=c(bound.eff,bound.fut):1-sided or bound=c(bound.low,bound.up):2-sided. nb the number of planned looks, bound.eff and bound.fut corresponds to the type of boundaries used for efficacy (i.e. reject H0) and futility (i.e. reject H1). bound.fut=0: No futility monitoring, 1: Lan deMets O.Brien Fleming, 2: Lan deMets Pocock. bound.low and bound.up the type of lower and upper boundaries used (1: Lan deMets O.Brien Fleming, 2: Lan deMets Pocock, 3: O.Brien Fleming, 4: Pocock). Default value = 1. |

`followup` |
Follow-up information, No fixed:c(0) (follow-up until the end of study); Fixed:c(1, durfollow) with durfollow is the duration of follow-up |

`dropout` |
Drop out information, No drop out:c(0); Drop out:c(1,gammae,gammac) with gammae the hazard drop out rates in experimental arm and control arm respectively. |

the datacheck function performs consistency checks on the arguments

coprimary documentation built on May 1, 2019, 10:10 p.m.

Embedding an R snippet on your website

Add the following code to your website.

For more information on customizing the embed code, read Embedding Snippets.