probanofix: Probabitility of event when the follow-up is no fixed

In coprimary: Sample Size Calculation for Two Primary Time-to-Event Endpoints in Clinical Trials

Description

In the design with variable follow-up, each subject is followed until the end of the study (Tf = infinite), i.e. subjects who are enrolled at the beginning of the enrolment phase are followed for a longer time than subjects who are enrolled later. When there are no drop outs (i.e. = (0,0), the probability of failure in each arm can be directly estimated using the formulation proposed by K Kim and A.A. Tsiatis (1990).

Usage

probanofix(surv,time,duraccrual,limit,gamma)

Arguments

surv	Survival estimates
time	Time estimate
duraccrual	Accrual duration, expressed in t time units
limit	Time limit to estimate the survival probability
gamma	the probability of observing an event by time t

Details

The probanofix function estimates the probability of event when the follow-up is no fixed

Value

probanofix: event probability at time limit

References

K. Kim, A.A. Tsiatis, Study duration for clinical trials with survival response and early stopping rule, Biometrics 46 (1990) 81-92

coprimary documentation built on May 1, 2019, 10:10 p.m.