Patterson (1951) combined balanced incomplete block designs (BIBDs) with Williams designs to get carryover balanced generalized Youden designs.
A matrix representing a BIBD. Rows represent blocks (subjects).
For each row of the design, a Williams design is constructed using the treatments of that row. The rows of the resulting designs are then combined. The treatments are numbered 1,...,trt. The entry (i,j) of the design corresponds to the treatment the i-th subject gets in the j-th period.
A matrix representing the experimental design.
The resultig design is only balanced properly if the input design actually is a BIBD.
This is NOT checked automatically. You have to do this by yourself, e.g. by applying
isGYD to your design.
BIBDs may be generated using
Patterson, H.D. (1951): Change-over trials. Journal of the Royal Statistical Society B 13, 256-271.
Wakeling, I.N. and MacFie, H.J.H. (1995): Designing consumer trials balanced for first and higher orders of carry-over effect when only a subset of k samples from t may be tested. Food Quality and Preference 6, 299-308.
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