dfcomb: Phase I/II Adaptive Dose-Finding Design for Combination Studies

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Phase I/II adaptive dose-finding design for combination studies. Several methods are proposed depending on the type of combinations: (1) the combination of two cytotoxic agents, and (2) combination of a molecularly targeted agent with a cytotoxic agent.

Author
Marie-Karelle Riviere and Jacques-Henri Jourdan
Date of publication
2016-06-21 22:42:45
Maintainer
Marie-Karelle Riviere <eldamjh@gmail.com>
License
GPL-3
Version
2.1-6

View on CRAN

Man pages

CombIncrease_next
Combination determination with logistic model
CombIncrease_sim
Combination design Simulator using Logistic model
CombPlateau_next
Combination determination for the combination of two agents...
CombPlateau_sim
Combination design Simulator for the combination of two...
dfcomb-package
Phase I and Phase I/II Adaptive Dose-Finding Design for...

Files in this package

dfcomb
dfcomb/configure.ac
dfcomb/src
dfcomb/src/logistic.cpp
dfcomb/src/arms.h
dfcomb/src/dfcomb.h
dfcomb/src/dfcomb.c
dfcomb/src/plateau.cpp
dfcomb/src/Makevars.in
dfcomb/src/CppBugs
dfcomb/src/CppBugs/cppbugs
dfcomb/src/CppBugs/cppbugs/mcmc.object.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.rng.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.stochastic.hpp
dfcomb/src/CppBugs/cppbugs/cppbugs.hpp
dfcomb/src/CppBugs/cppbugs/distributions
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.binomial.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.discrete.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.exponential.censored.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.exponential.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.multivariate.normal.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.bernoulli.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.gamma.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.uniform.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.beta.hpp
dfcomb/src/CppBugs/cppbugs/distributions/mcmc.normal.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.observed.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.math.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.model.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.dynamic.stochastic.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.rng.base.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.deterministic.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.dynamic.hpp
dfcomb/src/CppBugs/cppbugs/mcmc.jump.hpp
dfcomb/src/CppBugs/README.rst
dfcomb/src/Makevars.win
dfcomb/src/arms.c
dfcomb/NAMESPACE
dfcomb/R
dfcomb/R/dfcomb.R
dfcomb/MD5
dfcomb/DESCRIPTION
dfcomb/configure
dfcomb/man
dfcomb/man/dfcomb-package.Rd
dfcomb/man/CombIncrease_next.Rd
dfcomb/man/CombIncrease_sim.Rd
dfcomb/man/CombPlateau_sim.Rd
dfcomb/man/CombPlateau_next.Rd
dfcomb/configure.win
dfcomb/cleanup
dfcomb/tools
dfcomb/tools/ax_check_compile_flag.m4