dfcomb-package: Phase I/II Adaptive Dose-Finding Design for Combination...

dfcomb-packageR Documentation

Phase I/II Adaptive Dose-Finding Design for Combination Studies

Description

Phase I/II adaptive dose-finding design for combination studies where toxicity rates are supposed to increase with both agents.

Details

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Author(s)

Marie-Karelle Riviere [aut], Jacques-Henri Jourdan [aut, cre]

Maintainer: Jacques-Henri Jourdan <jacques-henri.jourdan@cnrs.fr>

References

Riviere MK, Yuan Y, Dubois F, Zohar S (2014). A Bayesian dose-finding design for drug combination clinical trials based on the logistic model. Pharm Stat, 13, 4:247-57.


dfcomb documentation built on Sept. 30, 2024, 5:06 p.m.