dfcomb-package: Phase I/II Adaptive Dose-Finding Design for Combination...

dfcomb-packageR Documentation

Phase I/II Adaptive Dose-Finding Design for Combination Studies

Description

Phase I/II adaptive dose-finding design for combination studies where toxicity rates are supposed to increase with both agents.

Details

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Author(s)

Marie-Karelle Riviere and Jacques-Henri Jourdan

Maintainer: Jacques-Henri Jourdan <jacques-henri.jourdan@normalesup.org>

References

Riviere MK, Yuan Y, Dubois F, Zohar S (2014). A Bayesian dose-finding design for drug combination clinical trials based on the logistic model. Pharm Stat, 13, 4:247-57.


dfcomb documentation built on Jan. 7, 2023, 5:30 p.m.