dtpcrm: Dose Transition Pathways for Continual Reassessment Method

Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.

Package details

AuthorChristina Yap [aut, cre], Daniel Slade [aut], Kristian Brock [aut], Yi Pan [aut]
MaintainerChristina Yap <yapchristina17@gmail.com>
LicenseGPL (>= 2)
Package repositoryView on CRAN
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dtpcrm documentation built on Aug. 20, 2019, 5:23 p.m.