gems: gems: Generalized Multistate Simulation Model


Simulate and analyze multistate models with general hazard functions. gems provides functionality for the preparation of hazard functions and parameters, simulation from a general multistate model and predicting future events. The multistate model is not required to be a Markov model and may take the history of previous events into account. In the basic version, it allows to simulate from transition-specific hazard function, whose parameters are multivariable normally distributed.


Nello Blaser, Luisa Salazar Vizcaya, Janne Estill, Cindy Zahnd, Bindu Kalesan, Matthias Egger, Olivia Keiser, Thomas Gsponer (2015). gems: An R Package for Simulating from Disease Progression Models. Journal of Statistical Software, 64(10), 1-22. URL

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