Nothing
## Case Study: Design of a Proof-of-Concept (PoC) trial in Crohn's disease
## See Section 5 of the vignette JSS-gsbDesign.pdf for more information.
set.seed(155)
desPoC1 <- gsbDesign(nr.stages = 1, patients = c(40, 40),
sigma = c(88, 88), criteria.success = c(0, 0.95),
criteria.futility = c(NA, NA))
simPoC1 <- gsbSimulation(truth = c(-50, 100, 60),
type.update = "treatment effect", method = "numerical integration")
ocPoC1 <- gsb(desPoC1, simPoC1)
summary(ocPoC1, atDelta = c(0, 50))
desPoC2 <- gsbDesign(nr.stages = 1, patients = c(20, 20),
sigma = c(88, 88), criteria.success = c(0, 0.975, 50, 0.5),
criteria.futility = c(40, 0.9))
simPoC2 <- gsbSimulation(truth = c(0, 70, 60),
type.update = "treatment effect", method = "numerical integration")
ocPoC2 <- gsb(desPoC2, simPoC2)
summary(ocPoC2, atDelta = c(0, 40, 50, 60))
desPoC4 <- gsbDesign(nr.stages = 2, patients = c(20, 20),
sigma = c(88, 88), criteria.success = c(0, 0.975, 50, 0.5),
criteria.futility = c(40, 0.9))
simPoC4 <- gsbSimulation(truth = c(0, 70, 60),
type.update = "treatment effect", method = "numerical integration")
ocPoC4 <- gsb(desPoC4, simPoC4)
summary(ocPoC4, atDelta = c(0, 40, 50, 60, 70))
SPoC4 <- summary(ocPoC4, atDelta = c(0, 40, 50, 60, 70))
desPoC5 <- gsbDesign(nr.stages = 2, patients = c(10, 20),
sigma = c(88, 88), criteria.success = c(0, 0.975, 50, 0.5),
criteria.futility = c(40, 0.9), prior.control = c(49, 20))
simPoC5 <- gsbSimulation(truth = cbind(rep(c(30, 50, 70), each = 5),
c(30, 70, 80, 90, 100, 50, 90, 100, 110, 120, 70, 110, 120, 130, 140)),
nr.sim = 20000, type.update = "per arm", method = "simulation",
grid.type = "manually")
ocPoC5 <- gsb(desPoC5, simPoC5)
## create Table 1
tS1 <- subset(ocPoC5$OC,type=="cumulative success" & delta.control==50 & stage=="stage 1")[,c("delta","value")]
tS2 <- subset(ocPoC5$OC,type=="cumulative success" & delta.control==50 & stage=="stage 2")[,"value"]
tF1 <- subset(ocPoC5$OC,type=="cumulative futility" & delta.control==50 & stage=="stage 1")[,"value"]
tF2 <- subset(ocPoC5$OC,type=="cumulative futility" & delta.control==50 & stage=="stage 2")[,"value"]
tN <- ceiling(subset(ocPoC5$OC,type=="sample size" & delta.control==50 & stage=="stage 2")[,"value"])
tSum <- cbind(tS1,tF1,tS2,tF2,tN)
colnames(tSum) <- c("$\\delta$","Interim\nsuccess","Interim\nfutility","Final\nsuccess","Final\nfutility","Expected N")
Any scripts or data that you put into this service are public.
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.