Description Usage Arguments Value Author(s) Examples

This function performs family based marker set based association (score test) based on the GEE_KM.

1 2 | ```
gskat_seq_cont(y,XC,Z,ID,impute.method="fixed",SNP.weights=NULL,
w_a=1,w_b=25,resampling=TRUE,pw="Rade",Uc=TRUE,sW=FALSE,np=10000)
``` |

`y` |
binary phenotype coded as 0, 1 |

`XC` |
covaraite matrix, including the intercept column |

`Z` |
SNP genotypes coded 0/1/2 (minor allele count) |

`ID` |
ID: Pedigree ID matrix, having four columns are the Family ID (FID), Individual ID (IID), Paternal ID (FAT), Maternal ID (MAT), respectively. |

`impute.method` |
default is fixed method i.e. fill with means |

`SNP.weights` |
If NULL, the default beta (1,25) desensity will be used, or a custimoized weight vector may be used |

`w_a` |
The first parameter of the beta density in the weight function |

`w_b` |
The second parameter of the beta density in the weight function |

`resampling` |
If TRUE, resampling will be applied |

`pw` |
r.v. used in the perturbation, "Norm"=Normal , "Rade"=Rademacher |

`Uc` |
Score centered or not |

`sW` |
standardize weights or not |

`np` |
No. of perturbed samples |

`p1` |
Returns asymptotic p-value |

`p2` |
Returns resampling p-value |

Xuefeng Wang

1 | ```
# gskat_seq_cont(y,XC=X,Z,ID)
``` |

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