Sachs: Protein Expression in Human Immune System Cells

In gss: General Smoothing Splines

Protein Expression in Human Immune System Cells

Description

Data concerning protein expression levels in human immune system cells under stimulations.

Usage

data(Sachs)

Format

A data frame containing 7466 cells, with flow cytometry measurements of 11 phosphorylated proteins and phospholipids, on the log10 scale of the original.

praf	Raf phosphorylated at S259.
pmek	Mek1/mek2 phosphorylated at S217/S221.
plcg	Phosphorylation of phospholipase C-\gamma on Y783.
pip2	Phophatidylinositol 4,5-biphosphate.
pip3	Phophatidylinositol 3,4,5-triphosphate.
p44.42	Erk1/erk2 phosphorylated at T202/Y204.
pakts473	AKT phosphorylated at S473.
pka	Phosphorylation of of protein kinase A substrates on 3 sites.
pkc	Phosphorylation of of protein kinase C substrates on S660.
p38	Erk1/erk2 phosphorylated at T180/Y182.
pjnk	Erk1/erk2 phosphorylated at T183/Y185.

Source

Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D. A., and Nolan, G. P. (2005), Causal protein-signaling networks derived from multiparameter single-cell data. Science, 308 (5732), 523–529.

gss documentation built on April 14, 2025, 1:09 a.m.