Nothing
## ---- include=FALSE-----------------------------------------------------------
knitr::opts_chunk$set(
comment = "#>",
collapse = TRUE,
dev = "ragg_png",
dpi = 72,
fig.retina = 2,
fig.align = "center",
out.width = "100%",
pngquant = "--speed=1 --quality=50"
)
## -----------------------------------------------------------------------------
library("hdnom")
## -----------------------------------------------------------------------------
data("smart")
x <- as.matrix(smart[, -c(1, 2)])
time <- smart$TEVENT
event <- smart$EVENT
y <- survival::Surv(time, event)
## ---- eval = FALSE------------------------------------------------------------
# suppressMessages(library("doParallel"))
# registerDoParallel(detectCores())
#
# fit <- fit_aenet(x, y, nfolds = 10, rule = "lambda.1se", seed = c(5, 7), parallel = TRUE)
# names(fit)
## ---- echo = FALSE------------------------------------------------------------
fit <- readRDS("fit.rds")
## -----------------------------------------------------------------------------
model <- fit$model
alpha <- fit$alpha
lambda <- fit$lambda
adapen <- fit$pen_factor
## ---- fig.width = 8, fig.height = 8, out.width = 600, out.height = 600--------
nom <- as_nomogram(
fit, x, time, event,
pred.at = 365 * 2,
funlabel = "2-Year Overall Survival Probability"
)
plot(nom)
## -----------------------------------------------------------------------------
val_int <- validate(
x, time, event,
model.type = "aenet",
alpha = alpha, lambda = lambda, pen.factor = adapen,
method = "bootstrap", boot.times = 10,
tauc.type = "UNO", tauc.time = seq(1, 5, 0.5) * 365,
seed = 42, trace = FALSE
)
print(val_int)
summary(val_int)
## ---- fig.width = 8, fig.height = 8, out.width = 500, out.height = 500--------
plot(val_int)
## ---- fig.width = 8, fig.height = 8, out.width = 500, out.height = 500--------
x_new <- as.matrix(smart[, -c(1, 2)])[1001:2000, ]
time_new <- smart$TEVENT[1001:2000]
event_new <- smart$EVENT[1001:2000]
val_ext <- validate_external(
fit, x, time, event,
x_new, time_new, event_new,
tauc.type = "UNO",
tauc.time = seq(0.25, 2, 0.25) * 365
)
print(val_ext)
summary(val_ext)
plot(val_ext)
## -----------------------------------------------------------------------------
cal_int <- calibrate(
x, time, event,
model.type = "aenet",
alpha = alpha, lambda = lambda, pen.factor = adapen,
method = "bootstrap", boot.times = 10,
pred.at = 365 * 5, ngroup = 3,
seed = 42, trace = FALSE
)
print(cal_int)
summary(cal_int)
## ---- fig.width = 8, fig.height = 8, out.width = 500, out.height = 500--------
plot(cal_int, xlim = c(0.5, 1), ylim = c(0.5, 1))
## ---- fig.width = 8, fig.height = 8, out.width = 500, out.height = 500--------
cal_ext <- calibrate_external(
fit, x, time, event,
x_new, time_new, event_new,
pred.at = 365 * 5, ngroup = 3
)
print(cal_ext)
summary(cal_ext)
plot(cal_ext, xlim = c(0.5, 1), ylim = c(0.5, 1))
## ---- fig.width = 9, fig.height = 6, out.width = 600, out.height = 400--------
kmplot(
cal_int,
group.name = c("High risk", "Medium risk", "Low risk"),
time.at = 1:6 * 365
)
kmplot(
cal_ext,
group.name = c("High risk", "Medium risk", "Low risk"),
time.at = 1:6 * 365
)
## -----------------------------------------------------------------------------
cal_int_logrank <- logrank_test(cal_int)
cal_int_logrank
cal_int_logrank$pval
cal_ext_logrank <- logrank_test(cal_ext)
cal_ext_logrank
cal_ext_logrank$pval
## ---- fig.width = 8, fig.height = 6.4, out.width = 600, out.height = 480------
cmp_val <- compare_by_validate(
x, time, event,
model.type = c("lasso", "alasso"),
method = "cv", nfolds = 5, tauc.type = "UNO",
tauc.time = seq(0.25, 2, 0.25) * 365,
seed = 42, trace = FALSE
)
print(cmp_val)
summary(cmp_val)
plot(cmp_val)
plot(cmp_val, interval = TRUE)
## ---- fig.width = 8, fig.height = 6.4, out.width = 600, out.height = 480------
cmp_cal <- compare_by_calibrate(
x, time, event,
model.type = c("lasso", "alasso"),
method = "cv", nfolds = 5,
pred.at = 365 * 9, ngroup = 5,
seed = 42, trace = FALSE
)
print(cmp_cal)
summary(cmp_cal)
plot(cmp_cal, xlim = c(0.3, 1), ylim = c(0.3, 1))
## -----------------------------------------------------------------------------
predict(fit, x, y, newx = x[101:105, ], pred.at = 1:10 * 365)
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