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immunogenetr: A Comprehensive Toolkit for Clinical HLA Informatics
A comprehensive toolkit for clinical Human Leukocyte Antigen (HLA) informatics, built on 'tidyverse' <https://tidyverse.tidyverse.org/> principles and making use of genotype list string (GL string, Mack et al. (2023) <doi:10.1111/tan.15126>) for storing and computing HLA genotype data. Specific functionalities include: coercion of HLA data in tabular format to and from GL string; calculation of matching and mismatching in all directions, with multiple output formats; automatic formatting of HLA data for searching within a GL string; truncation of molecular HLA data to a specific number of fields; and reading HLA genotypes in HML files and extracting the GL string. This library is intended for research use. Any application making use of this package in a clinical setting will need to be independently validated according to local regulations.
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Package details |
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| Author | Nicholas Brown [cre, aut] (ORCID: <https://orcid.org/0000-0002-0046-2315>), Busra Coskun [aut] (ORCID: <https://orcid.org/0009-0008-6828-3453>) |
| Maintainer | Nicholas Brown <nicholas.brown@pennmedicine.upenn.edu> |
| License | GPL (>= 3) |
| Version | 1.2.0 |
| URL | https://github.com/k96nb01/immunogenetr_package https://doi.org/10.1016/j.humimm.2025.111619 |
| Package repository | View on CRAN |
| Installation |
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