Provides functions for the identification, classification, and ranking of influential nodes and candidate features from network and omics data. The package implements the Integrated Value of Influence (IVI) for integrative network centrality analysis, the SIR-based Influence Ranking (SIRIR) model for unsupervised influence ranking, and the Experimental data-based Integrative Ranking (ExIR) model for prioritizing candidate driver, biomarker, and mediator features from experimental omics data. Functions are provided for network reconstruction from adjacency matrices and data frames, topological analysis, centrality calculation, assessment of associations between centrality measures, and conditional probability analysis. ExIR supports bulk and single-cell omics data, including matrices, sparse matrices, data frames, tibbles, and Seurat objects.
Package details |
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| Author | Adrian Salavaty [aut, cre] (ORCID: <https://orcid.org/0000-0001-9320-5889>), Mirana Ramialison [ths], Peter D. Currie [ths] |
| Maintainer | Adrian Salavaty <abbas.salavaty@gmail.com> |
| License | GPL-3 |
| Version | 2.3.1 |
| URL | https://github.com/asalavaty/influential https://asalavaty.github.io/influential/ |
| Package repository | View on CRAN |
| Installation |
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