Description Usage Format Details See Also

A list of length two containing a one stage jointmeta1 fit and corresponding bootstrapped standard errors.

1 |

A list of 2 objects:

`onestagefit3`

an object of class

`jointmeta1`

`onestagefit3SE`

an object of class

`jointmeta1SE`

These are the results of using the `jointmeta1`

function to fit
a one stage joint meta model for multi-study data, and also the bootstrap
results of applying the `jointmetaSE`

function to the resulting model
fit. The data used is the `simdat2`

data available in the
`joineRmeta`

package. This data has three levels, namely the
longitudinal measurements at level 1, nested within individuals (level 2)
who are themselves nested within studies (level 3).

The format of this model is as follows. The structure of the longitudinal sub-model is:

*Y_{kij} = β_{10} + β_{11}time + β_{12}treat +
β_{13}study + β_{14}treat*study + b^{(2)}_{0ki} + b^{(2)}_{1ki}time
+ ε_{kij}*

*Y_{kij}* represents the continuous longitudinal outcome for the
*i*th individual in the *k*th study at the *j*th time point,
fixed effect coefficients are represented by *β*, random effects
coefficients by *b* and the measurement error by *ε*. For
the random effects the superscript of 2 indicates that these are
individual level, or level 2 random effects. This means they take can take
a unique value for each individual in the dataset. The longitudinal time
variable is represented by *time*, and the treatment assignment
variable (a binary factor) is represented by *treat*. The study
membership variable, a factor variable, is represented by *study*.

The survival sub-model had format:

*λ_{ki}(t) = λ_{0k}(t)exp(β_{21}treat +
α^{(2)}(b^{(2)}_{0ki} + b^{(2)}_{1ki}time)) *

In the above equation, *λ_{ki}(t)* represents the survival time
of the individual *i* in study *k*, and *λ_{0k}(t)*
represents the unspecified baseline hazard which is stratified by study.
The fixed effect coefficients are represented by *β* terms. A
proportional random effects only association structure links the
sub-models, with *α^{(2)}* representing the association between
the longitudinal and survival outcomes attributable to the deviation of the
individual in question from the population mean longitudinal trajectory.

We differentiate between the fixed effect coefficients in the longitudinal and the survival sub-models by varying the first number present in the subscript of the fixed effect, which takes a 1 for coefficients from the longitudinal sub-model and a 2 for coefficients from the survival sub-model.

This model accounts for between study heterogeneity by including study membership and interactions between the study membership and the treatment assignment in the fixed effects of the longitudinal sub-model, and by stratifying the baseline hazard by study in the survival sub-model.

These fits have been provided in this package for use with the package vignette, see the vignette for more information.

The code used to fit this one stage model was:

```
onestagefit3<-jointmeta1(data = jointdat, long.formula = Y ~ 1 +
time + treat*study, long.rand.ind = c('int', 'time'), sharingstrct =
'randprop', surv.formula = Surv(survtime, cens) ~ treat, study.name =
'study', strat = T)
```

And the code used to bootstrap the model was:

```
onestagefit3SE<-jointmetaSE(fitted = onestagefit3, n.boot = 200,
overalleffects = list(long = list(c('treat1', 'treat1:study2'), c('treat1',
'treat1:study3'), c('treat1', 'treat1:study4'), c('treat1',
'treat1:study5'))))
```

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