get_network_matrix: Function to calculate the network 'matrix' for a 'pathway'...

In kangar00: Kernel Approaches for Nonlinear Genetic Association Regression

Function to calculate the network matrix for a pathway object

Description

get_network_matrix creates the adjacency matrix representing the gene-gene interaction structure within a particular pathway. Note that a KEGG kgml file is downloaded and saved in the working directory.

Usage

## S4 method for signature 'pathway'
get_network_matrix(object, directed = TRUE, method = "auto")

Arguments

object	A pathway object identifying the pathway for which gene interaction infomation should be extracted. Here, KEGG IDs of format 'hsa00100' are used and information is downloaded from the KEGG database.
directed	A logical argument, stating whether the network matrix should return directed (TRUE) or undirected (FALSE) links.
method	Download method to be used for downloading files, passed to via KEGGgraph::retrieveKGML to utils::download.file function. Currently supports 'auto' (default), 'internal', 'wininet' (Windows only), 'libcurl', 'wget' and 'curl'.

Value

get_network_matrix returns the modified pathway object, where the slots adj and sign are altered according to the downloaded information in the KEGG kgml file.

Author(s)

Stefanie Friedrichs, Patricia Burger, Juliane Manitz

kangar00 documentation built on Dec. 6, 2022, 9:06 a.m.