# secondary: Derive secondary PK parameters. In linpk: Generate Concentration-Time Profiles from Linear PK Systems

## Description

Derive secondary PK parameters.

## Usage

 `1` ```secondary(x, From = NULL, To = NULL, include.dose.times = T) ```

## Arguments

 `x` A object of class `pkprofile`. `From` A vector of interval start times. The defaults is the times of the doses. `To` A vector of interval end times. The defaults is the time of the next dose, or last observation time. `include.dose.times` Should dose times (and end of infusion times) be considered in addition to the simulation times?

## Value

A `data.frame` with one row for each time interval and with the following columns:

`From`

The time of the start of the interval. Can differ from the specified start time because it always corresponds to an actual data point.

`To`

The time of the end of the interval. Can differ from the specified end time because it always corresponds to an actual data point.

`N`

The number of distinct data points in the interval used to derive `AUC`, `Cmax`, etc.

`Ctrough`

Concentration at the time of dose (i.e. just prior to the dose). Only present if the start of the interval corresponds to a dose time.

`Cmin`

Minimum concentration over the interval.

`Tmin`

Time of the minimum concentration over the interval.

`Cmax`

Maximum concentration over the interval.

`Tmax`

Time of the maximum concentration over the interval.

`Cave`

Average concentration over the interval (calculated by the trapezoid rule).

`AUC`

Area under the concentration-time curve over the interval (calculated by the trapezoid rule).

## Examples

 ``` 1 2 3 4 5 6 7 8 9 10 11``` ```t.obs <- seq(0, 24*4, 0.1) y <- pkprofile(t.obs, cl=0.25, vc=5, ka=1, dose=list(t.dose=0, amt=1, addl=6, ii=12)) secondary(y) secondary(y, 0, 48) secondary(y, 0, Inf) sum(secondary(y)\$AUC) # Same as above plot(y) with(secondary(y), points(Tmax, Cmax, pch=19, col="blue")) with(secondary(y), points(Tmin, Cmin, pch=19, col="red")) with(secondary(y), points(From, Ctrough, pch=19, col="green")) with(secondary(y), points(From + 6, Cave, pch=19, col="purple", cex=2)) ```

linpk documentation built on June 12, 2018, 5:04 p.m.