exmodel_exdata: Example model and data

In mapbayr: MAP-Bayesian Estimation of PK Parameters

Example model and data

Description

A collection of example models and corresponding data to test and explore mapbayr.

Usage

exmodel(
  num = 1,
  add_exdata = TRUE,
  cache = TRUE,
  quiet = getOption("mrgsolve_mread_quiet", TRUE),
  ...,
  ID = 1,
  clean_data = TRUE
)

exdata(num = 1, ID = 1, clean_data = TRUE)

Arguments

num	model number (see details)
add_exdata	should data be automatically loaded with the model
cache	read the model with mrgsolve::mread_cache()
quiet	don't print messages when compiling
...	passed to mrgsolve::mread() or mrgsolve::mread_cache()
ID	individual number to include in the data (from 1 to 8)
clean_data	remove useless columns and rows from the original data

Details

Available models are:

• 1: Base model. A simple monocompartmental PK model with inter-individual variability on absorption constant (KA), volume of distribution (VC) and clearance (CL). The residual error model is proportional.

• 6: Complex absorption model. Dual 0- and 1st orders absorption phenomenons.

• 301: Time-varying covariates. A continuous covariate (body weight "BW") and a categorical one (sex "SEX") influence the clearance parameter. In the corresponding dataset, the values randomly changes from one record to another within a single individual.

• 401: Metabolite. The PK model of both a parent drug and its metabolite.

An example dataset of eight (simulated) individuals is available for each model. Individuals differ in terms of sampling times (sparse or rich) and dosing regimen (single or multiple dosing).

Model code and data files are stored at the location given by system.file("exmodel", package = "mapbayr").

These models and data were created for the validation study of mapbayr published in CPT:Pharmacometrics & System Pharmacology. More models and full datasets can be accessed in a dedicated repository

Value

exmodel() reads and compiles code, and returns a (mrgmod) model object. exdata() returns a data.frame.

Source

https://github.com/FelicienLL/mapbayr-CPTPSP-2021

Examples

# Models can be loaded with data (the default), ready for parameter estimation
est <- mapbayest(exmodel())

# Number of subjects in dataset can be chosen up to 8 individuals
exdata(301, ID = c(5,8))

mapbayr documentation built on July 26, 2023, 5:16 p.m.