use_posterior: Use posterior estimation

In mapbayr: MAP-Bayesian Estimation of PK Parameters

Use posterior estimation

Description

Use posterior estimation

Usage

use_posterior(
  x,
  update_omega = FALSE,
  update_cov = TRUE,
  update_eta = TRUE,
  .zero_re = NULL,
  simplify = TRUE
)

Arguments

x	A mapbayests object.
update_omega	Update the OMEGA matrix with the variance-covariance matrix of estimation (a logical, default is FALSE).
update_cov	Update the values of covariates with the individual values (a logical, default is TRUE).
update_eta	Update the values of ETA with the final estimates (a logical, default is TRUE).
.zero_re	Set all elements of the OMEGA or SIGMA matrix to zero. Default is "both" if update_omega is FALSE, "sigma" otherwise. (possible values are "both", "sigma", "omega", "none")
simplify	a logical. If TRUE (the default) and only one ID, one mrgmod is returned instead of a list of length 1

Details

This function takes the results of an estimation (i.e. a mapbayests object) and return a modified mrgmod in order to perform a posteriori simulations. Modifications are:

• If update_eta is TRUE, the values of ETA are updated to the estimated values (instead of 0) in $PARAM.

• If update_cov is TRUE, the covariates values are updated to the values of the individual (instead of default model values) in $PARAM.

• If update_omega is TRUE, the values of OMEGA are updated with the variance-covariance matrix of estimation (i.e. an approximation of the a posteriori distribution) instead of the inter-individual variability (i.e. the a priori distribution). Use this command in order to derive a confidence interval of concentrations that reflects the uncertainty about parameter estimation when a large number of profiles are simulated. Note that if inter-individual variability was initially defined in multiple $OMEGA blocks in the model, they will be collapsed to a single full matrix (this is irreversible).

• Depending on the values of .zero_re, the elements of $OMEGA or $SIGMA can be set to zero, whether you want to simulate one profile, or several in order to derive confidence/prediction intervals. It does not handle time-varying covariates: only the first value will be used as the individual value.

Value

a mrgmod, or a list of mrgmod if there is more than 1 ID

Examples

library(magrittr)
est <- mapbayest(exmodel())
est %>%
  use_posterior() %>%
  mrgsolve::ev(amt = 50000) %>%
  mrgsolve::mrgsim()

mapbayr documentation built on July 26, 2023, 5:16 p.m.