maxcombo-package: The Group Sequential Max-Combo Test for Comparing Survival...

In maxcombo: The Group Sequential Max-Combo Test for Comparing Survival Curves

Description

This package contains functions for comparing survival curves using the max-combo test at a single timepoint or repeatedly at successive respective timepoints while controlling type I error (i.e., the group sequential setting), as published by Tom Prior (Prior 2020 Group sequential monitoring based on the maximum of weighted log-rank statistics with the Fleming-Harrington class of weights in oncology clinical trials). The max-combo test is a generalization of the weighted log-rank test, which itself is a generalization of the log-rank test, which is a commonly used statistical test for comparing survival curves, e.g., during or after a clinical trial as part of an effort to determine if a new drug or therapy is more effective at delaying undesirable outcomes than an established drug or therapy or a placebo.

Details

This package contains the following four functions:

• oogetdoublemaxcomboteststatistic

• oogetdoublemaxcombotestpvalue

• oogetdoublemaxcombocutoff

• oogetdoublemaxcombocutoffgroupsequential

A reasonable way to get started with using this package is to read the documentation for those functions in the order they are listed above.

Author(s)

Tom Prior <[e-mail] or [e-mail]>

Maintainer: Tom Prior <[e-mail] or [e-mail]>

References

Prior 2020 Group sequential monitoring based on the maximum of weighted log-rank statistics with the Fleming-Harrington class of weights in oncology clinical trials.

(Available at: https://doi.org/10.1177/0962280220931560)

maxcombo documentation built on Dec. 15, 2020, 5:29 p.m.