metaRMST: Meta-Analysis of RMSTD

R implementation of a multivariate meta-analysis of randomized controlled trials (RCT) with the difference in restricted mean survival times (RMSTD). Use this package with individual patient level data from an RCT for a time-to-event outcome to determine combined effect estimates according to 4 methods: 1) a univariate meta-analysis using observed treatment effects, 2) a univariate meta-analysis using effects predicted by fitted Royston-Parmar flexible parametric models, 3) multivariate meta-analysis with analytically derived covariance, 4) multivariate meta-analysis with bootstrap derived covariance. This package computes all combined effects and provides an RMSTD curve with combined effect estimates and their confidence intervals.

Getting started

Package details

AuthorIsabelle Weir [aut, cre], Lu Tian [aut], Ludovic Trinquart [aut]
MaintainerIsabelle Weir <>
Package repositoryView on CRAN
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metaRMST documentation built on May 2, 2019, 2:18 a.m.