AorticStenosisTrials: Aortic Stenosis RCT data

Description Usage Format Note References

Description

Data from 5 randomized controlled trials of transcatheter aortic valve replacement vs surgery in patients with Aortic Stenosis. The outcome is time until death from any cause. For each RCT, we reconstructed the individual patient data for each randomization group. We first extracted the time and survival probability coordinates from the Kaplan-Meier curves using the DigitizeIt software (http://www.digitizeit.de/). We used these coordinates, the total numbers of events, and the numbers of participants at risk to determine individual event times and event indicators. (Guyot, BMC Med Res Method 2012)

Usage

1

Format

An object of class data.frame with 5417 rows and 4 columns.

Note

Trial ID Trial Name Last observed time (months)*
----------------- ------------------- ---------------------
1 NOTION 24.0
2 PARTNER 63.3
3 SURTAVI 24.1
4 PARTNER2 36.1
5 USCoreValve 24.1

* minimum of the last observed times across the two randomization groups.

References

Sondergaard, L, Steinbruchel, DA, Ihlemann, N, Nissen, H, Kjeldsen, BJ, Peturs-son, P, Ngo, AT, Olsen, NT, Chang, Y, Franzen, OW and others. (2016). Two-year outcomes in patients with severe aortic valve stenosis randomized to transcatheter versus surgical aortic valve replacement. Circ Cardiovasc Interv 9(6)

Mack, MJ, Leon, MB, Smith, CR, Miller, DC, Moses, JW, Tuzcu, EM, Webb, JG, Douglas, PS, Anderson, WN, Blackstone, EH and others. (2015).5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet 385, 2477-2484.

Reardon, MJ, Van Mieghem, NM, Popma, JJ, Kleiman, NS, S√łndergaard, L, Mum-taz, M, Adams, DH, Deeb, GM, Maini, B, Gada, H and others. (2017). Surgical or transcatheter aortic-valve replacement in intermediate-risk patients. N Engl J Med 376(14), 1321-1331.

Leon, MB, Smith, CR, Mack, MJ, Makkar, RR, Svensson, LG, Kodali, SK, Thourani,VH, Tuzcu, EM, Miller, DC, Herrmann, HC and others. (2016). Transcatheter orsurgical aortic-valve replacement in intermediate-risk patients. N Engl J Med 2016(374), 1609-1620.

Deeb, GM, Reardon, MJ, Chetcuti, S, Patel, HJ, Grossman, PM, Yakubov, SJ,Kleiman, NS, Coselli, JS, Gleason, TG, Lee, JS and others. (2016). 3-year outcomes in high-risk patients who underwent surgical or transcatheter aortic valve replacement. J Am Coll Cardiol 67(22), 2565-2574.

Guyot P, Ades AE, Ouwens MJ, et al. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol 2012; 12:9.


metaRMST documentation built on May 2, 2019, 2:18 a.m.