mixmeta: an Extended Mixed-Effects Modelling Framework for Meta-Analysis

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The package consists of a collection of functions to perform various meta-analytical models within a unified mixed-effects framework, including standard univariate fixed and random-effects meta-analysis and meta-regression, and non-standard extensions such as multivariate, multilevel, longitudinal, and dose-response models. The methodology is illustrated in detail in the article by Sera et al (see below).

Info on the mixmeta package

The package mixmeta is available on the Comprehensive R Archive Network (CRAN), with info at the related web page ( A development website is available on GitHub (

For a short summary of the functionalities of this package, refer to the main help page by typing:


in R after installation (see below).


The last version officially released on CRAN can be installed directly within R by typing:


R code in published articles

Peer-reviewed articles and documents provide R code illustrating methodological developments of mixmeta or replicating substantive results using this package. An updated version of the code will be available the GitHub ( or personal web page ( of the package maintainer.


Sera F, Armstrong B, Blangiardo M, Gasparrini A. An extended mixed-effects framework for meta-analysis. Statistics in Medicine. 2019;38(29):5429-5444 [freely available here]

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mixmeta documentation built on June 12, 2021, 5:07 p.m.