Differential expression analysis of RNA-Seq data when replicates under two conditions are available is performed. First, mixtures of Negative Binomial distributions are fitted on the data in order to estimate the dispersions, then the Wald test is computed.
|Author||Elisabetta Bonafede, Cinzia Viroli|
|Date of publication||2015-05-02 14:11:25|
|Maintainer||Cinzia Viroli <email@example.com>|
filter.em: Internal function that perform pre-filtering
fit.mixtNB: Fitting mixtures of Negative Binomials in RNA-Seq data
fun.a: Internal function for the Newton-Raphson step of the EM...
mixtNB-package: DE Analysis of RNA-Seq Data by Mixtures of Negative Binomials
wald.test: Wald test for performing DE analysis