Description Usage Arguments Details Value References See Also Examples
The function computes the intersection-union z-test which forms the basis for the
sample size and power calculations in function power.known.var
.
1 | mpe.z.test(X, Y, Sigma, conf.level = 0.975)
|
X |
matrix with observations of group 1 in rows |
Y |
matrix with obersvations of group 2 in rows |
Sigma |
known covariance matrix. |
conf.level |
confidence level of the interval. |
The function computes the intersection-union z-test which forms the basis for the
sample size and power calculations for continuous multiple co-primary
endpoints with known covariance as computed by function power.known.var
.
The implementation is based on the formulas given in the references below.
The null hypothesis reads mu_Tk-mu_Ck <= 0 for
at least one k in {1,...,K} where Tk is treatment k,
Ck is control k and K is the number of co-primary endpoints (i.e. number of
columns of X
and Y
).
Object of class "mpe.test"
.
Sugimoto, T. and Sozu, T. and Hamasaki, T. (2012). A convenient formula for sample size calculations in clinical trials with multiple co-primary continuous endpoints. Pharmaceut. Statist., 11: 118-128. doi:10.1002/pst.505
Sozu, T. and Sugimoto, T. and Hamasaki, T. and Evans, S.R. (2015). Sample Size Determination in Clinical Trials with Multiple Endpoints. Springer Briefs in Statistics, ISBN 978-3-319-22005-5.
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