Nuclei: Brain activity in 14 brain regions for 71 individuals

In multiDimBio: Multivariate Analysis and Visualization for Biological Data

Description

The activity in 14 brain nuclei were measured in rats that were in one of four groups: 1) Non-stressed, Control 2) Stressed, Control 3) Non-stressed, Vinclozolin 4) Stressed, Vinclozolin

Usage

data(Nuclei)

Format

A numeric matrix with 71 individuals as rows and the activity of 14 brain nuclei as columns. NAs indicate missing data.

Details

Two different cohorts of male rats of the F3 generation of Vinclozolin (Vinclozolin-Lineage) and Vehicle Control (Control-Lineage) Lineages produced at Washington State University are shipped to the University of Texas on the day after weaning. Rats are randomly pair-housed (one Control-Lineage and one Vinclozolin-Lineage animal) and remain in these dyads throughout the duration of the study. Half of the dyads are randomly chosen to receive chronic restraint stress (CRS) treatment for 6 hours daily for 21 consecutive days commencing 1 hr after lights off. Activity in 14 brain nuclei were measured at the end of the study.

Source

The data are provided courtesy of David Crews at the University of Texas at Austin.

References

Crews, D, R Gillette, SV Scarpino, M Manikkam, MI Savenkova, MK Skinner. 2012. Epigenetic Transgenerational Alterations to Stress Response in Brain Gene Networks and Behavior. Proc. Natl. Acad. Sci. USA. 109 (23). 9143 - 9148.

Examples

data(Nuclei)

multiDimBio documentation built on April 14, 2020, 5:41 p.m.