ndmm: Newly diagnosed multiple myeloma
In multinma: Bayesian Network Meta-Analysis of Individual and Aggregate Data

ndmm_ipd

R Documentation

Newly diagnosed multiple myeloma

Description

Three data frames, ndmm_ipd, ndmm_agd, and ndmm_agd_covs containing (simulated) individual patient data (IPD) from three studies and aggregate data (AgD) from two studies on newly diagnosed multiple myeloma. The outcome of interest is progression-free survival after autologous stem cell transplant. The IPD studies in ndmm_ipd provide event/censoring times and covariate values for each individual. The AgD studies provide reconstructed event/censoring times from digitized Kaplan-Meier curves in ndmm_agd and covariate summaries in ndmm_agd_covs, obtained from published trial reports. The data are constructed to resemble those used by \insertCiteLeahy2019;textualmultinma.

Usage

ndmm_ipd

ndmm_agd

ndmm_agd_covs

Format

The individual patient data are contained in a data frame ndmm_ipd with 1325 rows, one per individual, and 10 variables:

study, studyf: study name
trt, trtf: treatment name
eventtime: event/censoring time
status: censoring indicator (0 = censored, 1 = event)
age: age (years)
iss_stage3: ISS stage 3 (0 = no, 1 = yes)
response_cr_vgpr: complete or very good partial response (0 = no, 1 = yes)
male: male sex (0 = no, 1 = yes)

The reconstructed Kaplan-Meier data for the aggregate studies are contained in a data frame ndmm_agd with 2819 rows and 6 variables:

study, studyf: study name
trt, trtf: treatment name
eventtime: event/censoring time
status: censoring indicator (0 = censored, 1 = event)

The covariate summaries extracted from published reportes for the aggregate studies are contained in a data frame ndmm_agd_covs with 4 rows, one per study arm, and 15 columns:

study, studyf: study name
trt, trtf: treatment name
sample_size: sample size in each arm
age_min, age_iqr_l, age_median, age_iqr_h, age_max, age_mean, age_sd: summary statistics for age (years)
iss_stage3: proportion of participants with ISS stage 3
response_cr_vgpr: proportion of participants with complete or very good partial response
male: proportion of male participants