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Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.
Package details |
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Author | Matthew Fidler [aut, cre] (<https://orcid.org/0000-0001-8538-6691>), Vipul Mann [aut], Vishal Sarsani [aut] (<https://orcid.org/0000-0002-9272-3438>), Christian Bartels [ctb], Bill Denney [aut] (<https://orcid.org/0000-0002-5759-428X>) |
Maintainer | Matthew Fidler <matthew.fidler@gmail.com> |
License | GPL (>= 3) |
Version | 3.0.2 |
URL | https://nlmixr2.github.io/nlmixr2extra/ https://github.com/nlmixr2/nlmixr2extra/ |
Package repository | View on CRAN |
Installation |
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