theoFitOde: Example single dose Theophylline ODE model

In nlmixr2extra: Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions

Example single dose Theophylline ODE model

Description

This is a nlmixr2 model that is pre-run so that it can be used in package testing and development. It is regenerated whenever binaries of nlmixr2extra are created. If there is a binary incompatability between the fit objects, a simple rerun of the installation will fix this nlmixr2 fit object.

Format

A (modified) data frame with 132 rows and 22 columns.

ID

Patient identifier

TIME

Time (hr)

DV

Dependent variable (concentration)

PRED

Predictions without any between subject variability

RES

Population Residual

WRES

Weighted Residuals under the FO assumption

IPRED

Individual Predictions

IRES

Individual Residuals

IWRES

Individual Weighted Residuals

CPRED

Conditional Prediction under the FOCE assumption

CRES

Conditional Residuals under the FOCE assumption

CWRES

Conditional Weighted Residuals under the FOCE assumption

eta.ka

Between subject changes for ka

eta.cl

Between subject changes for v

depot

amount in the depot compartment

center

amount in the central compartment

ka

Individual ka values

cl

Individual cl values

v

Individual volume of distribution

tad

Time after dose

dosenum

Dose number

nlmixr2extra documentation built on April 12, 2025, 1:41 a.m.