NEWS.md

In nonmem2rx: Converts 'NONMEM' Models to 'rxode2'

nonmem2rx 0.1.6

• Add more flexible replacement of ETA and other values #188

• Add ability to use nonmem2rx with a NONMEM control stream text input

nonmem2rx 0.1.5

• Be more forgiving in the validation and remove IDs without observations when solving the IPRED problem.

• Binary linkage to dparser changed to structure only, meaning nonmem2rx may not have to be updated if dparser is updated.

nonmem2rx 0.1.4

• When reading NONMEM results from xml will try nm: prefixed tags and non-nm: prefixed tags.

• Omega and Sigma prior estimates are currently ignored (theta priors were already ignored)

• Improve reading in theta values from the xml

• Read all NONMEM files using latin1 encoding to allow single byte parser to work

• When lines in the NONMEM input dataset start with # they are now ignored.

• When all IDs are zero, NONMEM assumes restarting time gives different IDs; this is now reflected in NONMEM translation of IDs.

• With linCmt() parsing, expand the scope of conflicting parameters that will be renamed with an import.

• Added better parsing for ELSE where there is another IF on the next line.

• Prefixed conflicting VP with rxm. when linCmt() models to be more accommodating when importing linear compartment models.

nonmem2rx 0.1.3

• Added explicit requirement for rxode2 2.0.13

• Added support of DADT(#) statements on the right side of the equation, i.e. DADT(3) = DADT(1) + DADT(2) (#164)

• Added support of ADVAN#, TRANS# (#161)

• Added more NONMEM-specific solving options

• Fixed security related format issues as requested by CRAN #167

• Now omega, thetaMat, dfObs and dfSub are incorporated into model function (by default). You can change this with the nonmem2rx keep argument

• Using the rxode2 2.0.13 makes sure that the solves for models where the endpoint is not determined in the typical nlmixr2 style will validate more often (due to a bug in solving in rxode2).

nonmem2rx 0.1.2

• Added support for ADVAN5 and ADVAN7 models

• Add parsing of accept/ignore characters for example IGNORE=(C='C') (See Issue #140)

• Add more robust reading of NONMEM information (and add source) in nminfo() (See issue #142)

• Since NONMEM does not protect divide by zeros by default, the default for solveZero is changed to solveZero = TRUE for nonmem2rx objects.

• Fixed bug for renaming eta and theta when they are renamed so that the ui$iniDf does not match the theta# or eta# (Issue #153)

• Turned off testing of the as.nonmem2rx example since it took too much time (according to CRAN)

nonmem2rx 0.1.1

• Fix internal memory issue (LTO, valgrind etc)

nonmem2rx 0.1.0

• Added a NEWS.md file to track changes to the package.

nonmem2rx documentation built on April 3, 2025, 11:05 p.m.