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#' \code{npregfast}: Nonparametric Estimation of
#' Regression Models with Factor-by-Curve Interactions.
#'
#'
#' This package provides a method for obtain nonparametric estimates of regression
#' models using local polynomial kernel smoothers or splines. Particular
#' features of the package
#' are facilities for fast smoothness estimation, and the calculation of their
#' first and second derivative. Users can define the smoothers parameters.
#' Confidence intervals calculation is provided by bootstrap methods.
#' Binning techniques were applied to speed up computation in the estimation
#' and testing processes.
#'
#'\code{npregfast} is designed along lines similar to those of other \code{R}
#'regression packages. The main function of the library is \code{frfast}
#'which, by default, fits a nonparametric regression model based on local
#'polynomial kernel smoothers. Note that through the argument \code{formula}
#' users can decide to fit a model by taking or not taking the interaction
#' into account and by the argument \code{formula} it is posible to select
#' the type of smoother: kernel or splines. Numerical and graphical summaries
#' of the fitted object can be
#' obtained by using the generic functions, \code{print.frfast},
#' \code{summary.frfast} and \code{plot.frfast}. Another of these generic
#' functions is \code{predict.frfast}, which takes a fitted model of the
#' \code{frfast} class and, given a new data set of values of the covariate,
#' produces predictions.
#' As mentioned above, this package can be used to fit models taking into
#' account factor-by-curve interactions. In this framework, it will be
#' necessary to ascertain if the factor produces an effect on the response
#' and thus, there is a interaction or, in contrast, the estimated regression
#' curves are equal. To this end, the package provides the \code{globaltest}
#' function which answers this question through a bootstrap-based test.
#' If the factor results significant, then \code{plotdiff()} enables the user
#' to obtain a graphical representation that shows the differences between
#' the estimated curves (estimate, first or second derivative) for any set of
#' two levels of the factor. Additionally, with \code{critical()} it is possible
#' to obtain the value of the covariate that maximises the estimate and
#' first derivative of the function and the value of the covariate that equals
#' the second derivative to zero, for each of these levels. Again, to test if
#' these estimated points are equal for all levels, the package provides the
#' \code{localtest} function. Note that, to compare these points between
#' any set of two levels, a confidence interval for the difference can be
#' obtained by applying \code{criticaldiff()}.
#'
#'
#'
#'
#' For a listing of all routines in the NPRegfast package type:
#' \code{library(help="npregfast")}.
#'
#' View a \href{http://sestelo.shinyapps.io/npregfast}{demo Shiny app}
#' or see the full \href{https://github.com/sestelo/npregfast}{README} on GitHub.
#'
#'
#' @author Marta Sestelo, Nora M. Villanueva and Javier Roca-Pardinas.
#'
#' @references
#' Efron, B. (1979). Bootstrap methods: another look at the jackknife.
#' Annals of Statistics, 7, 1--26.
#'
#' Efron, E. and Tibshirani, R. J. (1993). An introduction to the Bootstrap.
#' Chapman and Hall, London.
#'
#' Huxley, J. S. (1924). Constant differential growth-ratios and their
#' significance. Nature, 114:895--896.
#'
#' Sestelo, M. (2013). Development and computational implementation of
#' estimation and inference methods in flexible regression models.
#' Applications in Biology, Engineering and Environment. PhD Thesis, Department
#' of Statistics and O.R. University of Vigo.
#'
#' Sestelo, M. and Roca-Pardinas, J. (2011). A new approach to estimation of
#' length-weight relationship of \eqn{Pollicipes} \eqn{pollicipes}
#' (Gmelin, 1789) on the Atlantic coast of Galicia (Northwest Spain): some
#' aspects of its biology and management. Journal of Shellfish Research,
#' 30(3), 939--948.
#'
#' Sestelo, M., Villanueva, N.M., Meira-Machado, L., Roca-Pardinas, J. (2017).
#' npregfast: An R Package for Nonparametric Estimation and Inference in Life
#' Sciences. Journal of Statistical Software, 82(12), 1-27.
#'
#' Wand, M. P. and Jones, M. C. (1995). Kernel Smoothing. Chapman & Hall, London.
#'
#'
#'
#'
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