pathwayTMB: Pathway Based Tumor Mutational Burden

A systematic bioinformatics tool to develop a new pathway-based gene panel for tumor mutational burden (TMB) assessment (pathway-based tumor mutational burden, PTMB), using somatic mutations files in an efficient manner from either The Cancer Genome Atlas sources or any in-house studies as long as the data is in mutation annotation file (MAF) format. Besides, we develop a multiple machine learning method using the sample's PTMB profiles to identify cancer-specific dysfunction pathways, which can be a biomarker of prognostic and predictive for cancer immunotherapy.

Package details

AuthorJunwei Han [aut, cre, cph], Xiangmei Li [aut]
MaintainerJunwei Han <hanjunwei1981@163.com>
LicenseGPL (>= 2)
Version0.1.1
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("pathwayTMB")

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pathwayTMB documentation built on Oct. 10, 2021, 5:07 p.m.