inst/doc/simulation_study_real.R

In penetrance: Methods for Penetrance Estimation in Family-Based Studies

## ----setup, include=FALSE-----------------------------------------------------
knitr::opts_chunk$set(echo = TRUE)
library(penetrance)
library(ggplot2)
library(scales)

## -----------------------------------------------------------------------------
dat <- test_fam2

## ----eval=FALSE---------------------------------------------------------------
# # Set the random seed
# set.seed(2024)
# 
# # Set the prior
# prior_params <- list(
#     asymptote = list(g1 = 1, g2 = 1),
#     threshold = list(min = 5, max = 30),
#     median = list(m1 = 2, m2 = 2),
#     first_quartile = list(q1 = 6, q2 = 3)
# )
# 
# # Set the allele frequency for MLH1 based on PanelPRO Database
# prevMLH1 <- 0.0004453125
# 
# # We use the default baseline (non-carrier) penetrance
# print(baseline_data_default)
# 
# # We run the estimation procedure with one chain and 20k iterations
# out_sim <- penetrance(
#     pedigree  = dat, twins = NULL, n_chains = 1, n_iter_per_chain = 20000,
#     ncores = 2, baseline_data = baseline_data_default , prev = prevMLH1,
#     prior_params = prior_params, burn_in = 0.1, median_max = TRUE,
#     ageImputation = FALSE, removeProband = FALSE
# )