| Organ System | 0 Points | 1 Point | 2 Points | 3 Points | | :------ | :-- | :-- | :-- | :-- | | Respiratory (0-3 points) | | | | | | | | Any respiratory support | IMV | IMV | | PaO~2~:FiO~2~ | ≥ 400 | < 400 | < 200 | < 100 | | SpO~2~:FiO~2~ | ≥ 292 | < 292 | < 220 | < 148 | | Cardiovascular (0-6 points; sum of medications, Lactate, and MAP) | | | | | | Systemic Vasoactive Medications | No medications | 1 medication | 2 or more medications | | | Lactate (mmol/L) | < 5 | 5 ≤ Lactate < 11 | ≥ 11 | | | Age (months) adjusted MAP (mmHg) | | | | | | 0 ≤ Age < 1 | ≥ 31 | 17 ≤ MAP < 31 | < 17 | | | 1 ≤ Age < 12 | ≥ 39 | 25 ≤ MAP < 39 | < 25 | | | 12 ≤ Age < 24 | ≥ 44 | 31 ≤ MAP < 44 | < 31 | | | 24 ≤ Age < 60 | ≥ 45 | 32 ≤ MAP < 45 | < 32 | | | 60 ≤ Age < 144 | ≥ 49 | 36 ≤ MAP < 49 | < 36 | | | 144 ≤ Age < 216 | ≥ 52 | 38 ≤ MAP < 52 | < 38 | | | Coagulation (0-2 points; 1 for each lab; max of 2 points) | | | | | | Platelets (1000/μL) | ≥ 100 | < 100 | | | | INR | ≤ 1.3 | > 1.3 | | | | D-Dimer (mg/L FEU) | ≤ 2 | > 2 | | | | Fibrinogen (mg/dL) | ≥ 100 | < 100 | | | | Neurologic (0-2 points) | | | | | | | GCS ≥ 11 | GCS ≤ 10 | Bilaterally fixed pupils | | | Endocrine (0-1 point) | | | | | | Blood Glucose (mg/dL) | 50 ≤ Blood Glucose ≤ 150 | < 50; or > 150 | | | | Immunologic (0-1 point; point from ANC and/or ALC) | | | | | | ANC (cells/mm^3^) | ≥ 500 | < 500 | | | | ALC (cells/mm^3^) | ≥ 1000 | < 1000 | | | | Renal (0-1 point) | | | | | | Age (months) adjusted Creatinine (mg/dL) | | | | | | 0 ≤ Age < 1 | < 0.8 | ≥ 0.8 | | | | 1 ≤ Age < 12 | < 0.3 | ≥ 0.3 | | | | 12 ≤ Age < 24 | < 0.4 | ≥ 0.4 | | | | 24 ≤ Age < 60 | < 0.6 | ≥ 0.6 | | | | 60 ≤ Age < 144 | < 0.7 | ≥ 0.7 | | | | 144 ≤ Age < 216 | < 1.0 | ≥ 1.0 | | | | Hepatic (0-1 point; point from total bilirubin and/or ALT) | | | | | | Total Bilirubin (mg/dL) | < 4 | ≥ 4 | | | | ALT (IU/L) | ≤ 102 | > 102 | | |
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