coxDKplsDR: Fitting a Direct Kernel PLS model on the (Deviance) Residuals

In plsRcox: Partial Least Squares Regression for Cox Models and Related Techniques

Fitting a Direct Kernel PLS model on the (Deviance) Residuals

Description

This function computes the Cox Model based on PLSR components computed model with

• as the response: the Residuals of a Cox-Model fitted with no covariate

• as explanatory variables: a Kernel transform of Xplan.

It uses the package kernlab to compute the Kernel transforms of Xplan, then the package mixOmics to perform PLSR fit.

Usage

coxDKplsDR(Xplan, ...)

## Default S3 method:
coxDKplsDR(
  Xplan,
  time,
  time2,
  event,
  type,
  origin,
  typeres = "deviance",
  collapse,
  weighted,
  scaleX = TRUE,
  scaleY = TRUE,
  ncomp = min(7, ncol(Xplan)),
  modepls = "regression",
  plot = FALSE,
  allres = FALSE,
  kernel = "rbfdot",
  hyperkernel,
  verbose = TRUE,
  ...
)

## S3 method for class 'formula'
coxDKplsDR(
  Xplan,
  time,
  time2,
  event,
  type,
  origin,
  typeres = "deviance",
  collapse,
  weighted,
  scaleX = TRUE,
  scaleY = TRUE,
  ncomp = min(7, ncol(Xplan)),
  modepls = "regression",
  plot = FALSE,
  allres = FALSE,
  dataXplan = NULL,
  subset,
  weights,
  model_frame = FALSE,
  kernel = "rbfdot",
  hyperkernel,
  verbose = TRUE,
  model_matrix = FALSE,
  contrasts.arg = NULL,
  ...
)

Arguments

Xplan	a formula or a matrix with the eXplanatory variables (training) dataset
...	Arguments to be passed on to survival::coxph.
time	for right censored data, this is the follow up time. For interval data, the first argument is the starting time for the interval.
time2	The status indicator, normally 0=alive, 1=dead. Other choices are TRUE/FALSE (TRUE = death) or 1/2 (2=death). For interval censored data, the status indicator is 0=right censored, 1=event at time, 2=left censored, 3=interval censored. Although unusual, the event indicator can be omitted, in which case all subjects are assumed to have an event.
event	ending time of the interval for interval censored or counting process data only. Intervals are assumed to be open on the left and closed on the right, (start, end]. For counting process data, event indicates whether an event occurred at the end of the interval.
type	character string specifying the type of censoring. Possible values are "right", "left", "counting", "interval", or "interval2". The default is "right" or "counting" depending on whether the time2 argument is absent or present, respectively.
origin	for counting process data, the hazard function origin. This option was intended to be used in conjunction with a model containing time dependent strata in order to align the subjects properly when they cross over from one strata to another, but it has rarely proven useful.
typeres	character string indicating the type of residual desired. Possible values are "martingale", "deviance", "score", "schoenfeld", "dfbeta", "dfbetas", and "scaledsch". Only enough of the string to determine a unique match is required.
collapse	vector indicating which rows to collapse (sum) over. In time-dependent models more than one row data can pertain to a single individual. If there were 4 individuals represented by 3, 1, 2 and 4 rows of data respectively, then collapse=c(1,1,1,2,3,3,4,4,4,4) could be used to obtain per subject rather than per observation residuals.
weighted	if TRUE and the model was fit with case weights, then the weighted residuals are returned.
scaleX	Should the Xplan columns be standardized ?
scaleY	Should the time values be standardized ?
ncomp	The number of components to include in the model. The number of components to fit is specified with the argument ncomp. It this is not supplied, the maximal number of components is used.
modepls	character string. What type of algorithm to use, (partially) matching one of "regression", "canonical", "invariant" or "classic". See pls for details
plot	Should the survival function be plotted ?)
allres	FALSE to return only the Cox model and TRUE for additionnal results. See details. Defaults to FALSE.
kernel	the kernel function used in training and predicting. This parameter can be set to any function, of class kernel, which computes the inner product in feature space between two vector arguments (see kernels). The kernlab package provides the most popular kernel functions which can be used by setting the kernel parameter to the following strings: list("rbfdot") Radial Basis kernel "Gaussian" list("polydot") Polynomial kernel list("vanilladot") Linear kernel list("tanhdot") Hyperbolic tangent kernel list("laplacedot") Laplacian kernel list("besseldot") Bessel kernel list("anovadot") ANOVA RBF kernel list("splinedot") Spline kernel
hyperkernel	the list of hyper-parameters (kernel parameters). This is a list which contains the parameters to be used with the kernel function. For valid parameters for existing kernels are : sigma, inverse kernel width for the Radial Basis kernel function "rbfdot" and the Laplacian kernel "laplacedot". degree, scale, offset for the Polynomial kernel "polydot". scale, offset for the Hyperbolic tangent kernel function "tanhdot". sigma, order, degree for the Bessel kernel "besseldot". sigma, degree for the ANOVA kernel "anovadot". In the case of a Radial Basis kernel function (Gaussian) or Laplacian kernel, if hyperkernel is missing, the heuristics in sigest are used to calculate a good sigma value from the data.
verbose	Should some details be displayed ?
dataXplan	an optional data frame, list or environment (or object coercible by as.data.frame to a data frame) containing the variables in the model. If not found in dataXplan, the variables are taken from environment(Xplan), typically the environment from which coxDKplsDR is called.
subset	an optional vector specifying a subset of observations to be used in the fitting process.
weights	an optional vector of 'prior weights' to be used in the fitting process. Should be NULL or a numeric vector.
model_frame	If TRUE, the model frame is returned.
model_matrix	If TRUE, the model matrix is returned.
contrasts.arg	a list, whose entries are values (numeric matrices, functions or character strings naming functions) to be used as replacement values for the contrasts replacement function and whose names are the names of columns of data containing factors.

Details

If allres=FALSE returns only the final Cox-model. If allres=TRUE returns a list with the PLS components, the final Cox-model and the PLSR model. allres=TRUE is useful for evluating model prediction accuracy on a test sample.

Value

If allres=FALSE :

cox_DKplsDR

Final Cox-model.

If allres=TRUE :

tt_DKplsDR	PLSR components.
cox_DKplsDR	Final Cox-model.
DKplsDR_mod	The PLSR model.

Author(s)

Frédéric Bertrand
[e-mail]
http://www-irma.u-strasbg.fr/~fbertran/

References

plsRcox, Cox-Models in a high dimensional setting in R, Frederic Bertrand, Philippe Bastien, Nicolas Meyer and Myriam Maumy-Bertrand (2014). Proceedings of User2014!, Los Angeles, page 152.

Deviance residuals-based sparse PLS and sparse kernel PLS regression for censored data, Philippe Bastien, Frederic Bertrand, Nicolas Meyer and Myriam Maumy-Bertrand (2015), Bioinformatics, 31(3):397-404, doi:10.1093/bioinformatics/btu660.

See Also

coxph, plsr

Examples

data(micro.censure)
data(Xmicro.censure_compl_imp)

X_train_micro <- apply((as.matrix(Xmicro.censure_compl_imp)),FUN="as.numeric",MARGIN=2)[1:80,]
X_train_micro_df <- data.frame(X_train_micro)
Y_train_micro <- micro.censure$survyear[1:80]
C_train_micro <- micro.censure$DC[1:80]

(cox_DKplsDR_fit=coxDKplsDR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6))

#Fixing sigma to compare with plsDR on Gram matrix; should be identical
(cox_DKplsDR_fit=coxDKplsDR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,
hyperkernel=list(sigma=0.01292786)))

X_train_micro_kern <- kernlab::kernelMatrix(kernlab::rbfdot(sigma=0.01292786),
scale(X_train_micro))
(cox_DKplsDR_fit2=coxplsDR(~X_train_micro_kern,Y_train_micro,C_train_micro,ncomp=6,scaleX=FALSE))

(cox_DKplsDR_fit=coxDKplsDR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,
kernel="laplacedot",hyperkernel=list(sigma=0.01292786)))

X_train_micro_kern <- kernlab::kernelMatrix(kernlab::laplacedot(sigma=0.01292786),
scale(X_train_micro))
(cox_DKplsDR_fit2=coxplsDR(~X_train_micro_kern,Y_train_micro,C_train_micro,ncomp=6,scaleX=FALSE))

(cox_DKplsDR_fit=coxDKplsDR(~X_train_micro,Y_train_micro,C_train_micro,ncomp=6))
(cox_DKplsDR_fit=coxDKplsDR(~.,Y_train_micro,C_train_micro,ncomp=6,dataXplan=X_train_micro_df))

(cox_DKplsDR_fit=coxDKplsDR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,allres=TRUE))
(cox_DKplsDR_fit=coxDKplsDR(~X_train_micro,Y_train_micro,C_train_micro,ncomp=6,allres=TRUE))
(cox_DKplsDR_fit=coxDKplsDR(~.,Y_train_micro,C_train_micro,ncomp=6,allres=TRUE,
dataXplan=X_train_micro_df))


rm(X_train_micro,Y_train_micro,C_train_micro,cox_DKplsDR_fit)

plsRcox documentation built on Dec. 1, 2022, 1:31 a.m.