GetSecdAbso: Get the secondary metabolites of the absorbed drug...

Description Usage Arguments Details Value Note Author(s) References See Also Examples

Description

A function to get secondary metabolites of the absorbed drug constitutes.

Usage

1
GetSecdAbso(A,B,C,simidata,sim=80,filepath,design)

Arguments

A

The differential compounds dataset which is derived from the GetDiffData function.

B

The altered endogenous metabolites dataset which is derived from the GetEndo function.

C

The absorbed drug constitutes dataset which is derived from the GetAbso function.

simidata

The same compounds of drug and pre-dose metabolome data, which is derived from Simi.

sim

The parameter (percentage) for similarity analysis. Default: 80.

filepath

A character string indicating the path where the results may be saved in.

design

(optional) a study design dataset(data frame with required format).Use data(design) to see the detailed format. Default:"FALSE".

Details

nothing

Value

A folder named "SecondAbsorbedMetabolites" containing a file named "SecondAbsorbedMetabolites.xlsx" will be created automatically which is the list and data of secondary metabolites of the absorbed drug constitutes. And the foreground color of the same compounds produced by Simi will be marked with light blue. If the study design is given by right from, the meal times and sleep times will be marked as yellow and grey.

Note

The list of absorbed drug compounds was obtained by excluding compounds in B and C from that of A.

Author(s)

Mengci Li, Shouli Wang, Guoxiang Xie, Tianlu Chen and Wei Jia

References

1. Ke Lan, Wei Jia, et al. An Integrated Metabolomics and Pharmacokinetics Strategy for Multi-Component Drug Evaluation. (2010) Current Drug Metabolism.

2. Guoxiang Xie, Wei Jia, et al. Metabolic Fate of Tea Polyphenols in Humans. (2012) Journal of Proteome Research.

3. Ke Lan, Wei Jia, et al. Towards Polypharmacokinetics: Pharmacokinetics of Multicomponent Drug and Herbal Medicines Using a Metabolomics Approach. (2013) Evidence-Based Complementary and Alternative Medicine.

4. Wei Jia, Tai-ping Fan, et al. The polypharmacokinetics of herbal medicines. (2015) Science.

5. Guoxiang Xie, Wei Jia, et al. Poly-pharmacokinetic study of a multicomponent herbal medicine in healthy Chinese volunteers. (2017) Clinical Pharmacology&Therapeutics.

See Also

GetDiffData GetAbso GetEndo Simi

Examples

1
2
3
4
5
6
7
8
9
##---- Should be DIRECTLY executable !! ----
##-- ==>  Define data, use random,
##--	or do  help(data=index)  for the standard data sets.
data("A")
data("B")
data("C")
data("simidata")
data("design")
GetSecdAbso(A,B,C,simidata,sim=80,filepath=getwd(),design=FALSE)

polyPK documentation built on May 2, 2019, 12:37 a.m.