powerpkg: Power analyses for the affected sib pair and the TDT design
Version 1.5

(1) To estimate the power of testing for linkage using an affected sib pair design, as a function of the recurrence risk ratios. We will use analytical power formulae as implemented in R. These are based on a Mathematica notebook created by Martin Farrall. (2) To examine how the power of the transmission disequilibrium test (TDT) depends on the disease allele frequency, the marker allele frequency, the strength of the linkage disequilibrium, and the magnitude of the genetic effect. We will use an R program that implements the power formulae of Abel and Muller-Myhsok (1998). These formulae allow one to quickly compute power of the TDT approach under a variety of different conditions. This R program was modeled on Martin Farrall's Mathematica notebook.

Getting started

Package details

AuthorDaniel E. Weeks
Date of publication2012-10-11 18:57:17
MaintainerDaniel E. Weeks <weeks@pitt.edu>
LicenseGPL (>= 2)
Version1.5
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("powerpkg")

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powerpkg documentation built on May 30, 2017, 12:15 a.m.