powerpkg: Power analyses for the affected sib pair and the TDT design

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(1) To estimate the power of testing for linkage using an affected sib pair design, as a function of the recurrence risk ratios. We will use analytical power formulae as implemented in R. These are based on a Mathematica notebook created by Martin Farrall. (2) To examine how the power of the transmission disequilibrium test (TDT) depends on the disease allele frequency, the marker allele frequency, the strength of the linkage disequilibrium, and the magnitude of the genetic effect. We will use an R program that implements the power formulae of Abel and Muller-Myhsok (1998). These formulae allow one to quickly compute power of the TDT approach under a variety of different conditions. This R program was modeled on Martin Farrall's Mathematica notebook.

Author
Daniel E. Weeks
Date of publication
2012-10-11 18:57:17
Maintainer
Daniel E. Weeks <weeks@pitt.edu>
License
GPL (>= 2)
Version
1.5

View on CRAN

Man pages

fnfam
Internal function called by ntdt
fx
Internal function for the ptdt function
normplot
Power plotting demonstration
nsibs
A function to compute power of an affected sib pair design.
ntdt
Computes number of trios needed for a TDT study.
ntdt.q
Computes power of a TDT study as a function of the...
plotDom
plotDom creates power graphs for an affected sibpair linkage...
plotNsibs
plotNsibs: Create power plots for an affected sib pair...
plotNtdt
A function for plotting the results from ntdt.q
ptb
A power table for the TDT design
ptdt
Power for a TDT design

Files in this package

powerpkg
powerpkg/MD5
powerpkg/README
powerpkg/R
powerpkg/R/ptdt.R
powerpkg/R/ptb.R
powerpkg/R/plotNtdt.R
powerpkg/R/plotNsibs.R
powerpkg/R/plotDom.R
powerpkg/R/ntdt.R
powerpkg/R/ntdt.q.R
powerpkg/R/nsibs.R
powerpkg/R/normplot.R
powerpkg/R/fx.R
powerpkg/R/fnfam.R
powerpkg/NAMESPACE
powerpkg/man
powerpkg/man/ptdt.Rd
powerpkg/man/ptb.Rd
powerpkg/man/plotNtdt.Rd
powerpkg/man/plotNsibs.Rd
powerpkg/man/plotDom.Rd
powerpkg/man/ntdt.Rd
powerpkg/man/ntdt.q.Rd
powerpkg/man/nsibs.Rd
powerpkg/man/normplot.Rd
powerpkg/man/fx.Rd
powerpkg/man/fnfam.Rd
powerpkg/DESCRIPTION