plotDom creates power graphs for an affected sibpair linkage study.

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Description

plotDom plots the effects of dominance on sample size in an affected sibpair linkage study.

Usage

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plotDom(lsib = 1.2, alpha = 0.001, power = 0.85,...)

Arguments

lsib

is the relative risk ratio to a sibling.

alpha

Type 1 error rate (significane level)

power

is the power of the study to detect inkage under the (ideal) chosen conditions and parameters.

...

additional arguments for plot

Value

Creates a plot, and returns a table of the data that generated the plot. In this table, the first column gives the lambda off value, while the second column gives the corresponding number of affected sib pairs needed to have the desired power.

Warning

Makes the simplifying assumptions that (1) all families will have exactly two affected sibpairs; and that (2) the identity-by-descent status in the ASPs can be determined unambiguously

Note

These are based on a Mathematica notebook created by Martin Farrall.

Author(s)

Daniel E. Weeks

See Also

nsibs, plotNsibs

Examples

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## Plot the effects of dominance on sample size in an affected sibpair
## linkage study. Do this under the assumption that lambda sib is 1.2,
## and the desired power is 85 percent at an alpha level of 0.001. 

plotDom(lsib=1.2,alpha=0.001,power=0.85)