simu_time | R Documentation |
Simulate time-to-events for multiple scenarios
simu_time(dt, eventObj, clinInt, clinExt, seed, path)
dt |
a list of |
eventObj |
an object of class |
clinInt |
an object of class |
clinExt |
an object of class |
seed |
the seed of R‘s random number generator. Default is the first element of .Random.seed |
path |
file name for saving the output including folder path |
a list of matrix
containing simulated time-to-events information
# simulate patient-level data without covariates # simulate survival time following weibull distribution # simulate trial indicator and set hazard ratios sample = set_n(ssC = 10, ssE = 20, ssExt = 40) sample_hr <- simu_cov(ssObj = sample, HR = 1, driftHR=c(1,1.2), nsim = 10) # enrollment pattern, drop-out, analysis start time c_int = set_clin(gamma = 2, e_itv = 10, etaC = 0.5, CCOD = "fixed-first", CCOD_t = 64) c_ext = c_int # simulate time-to-event with a weibull distribution evt1 <- set_event(event = "weibull", shape = 0.8, lambdaC = 0.01) simu_time(dt = sample_hr, eventObj = evt1, clinInt = c_int, clinExt = c_ext) # simulate time-to-event with an exponential distribution evt2 <- set_event(event = "pwexp", t_itv = 1, lambdaC = c(0.1, 0.02)) simu_time(dt = sample_hr, eventObj = evt2, clinInt = c_int, clinExt = c_int)
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