qch: Query Composite Hypotheses

Provides functions for the joint analysis of Q sets of p-values obtained for the same list of items. This joint analysis is performed by querying a composite hypothesis, i.e. an arbitrary complex combination of simple hypotheses, as described in Mary-Huard et al. (2021) <doi:10.1093/bioinformatics/btab592> and De Walsche et al.(2023) <doi:10.1101/2024.03.17.585412>. In this approach, the Q-uplet of p-values associated with each item is distributed as a multivariate mixture, where each of the 2^Q components corresponds to a specific combination of simple hypotheses. The dependence between the p-value series is considered using a Gaussian copula function. A p-value for the composite hypothesis test is derived from the posterior probabilities.

Package details

AuthorTristan Mary-Huard [aut, cre] (<https://orcid.org/0000-0002-3839-9067>), Annaig De Walsche [aut] (<https://orcid.org/0000-0003-0603-1716>), Franck Gauthier [ctb] (<https://orcid.org/0000-0003-0574-065X>)
MaintainerTristan Mary-Huard <tristan.mary-huard@agroparistech.fr>
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:

Try the qch package in your browser

Any scripts or data that you put into this service are public.

qch documentation built on May 29, 2024, 8:11 a.m.