Provides functions for the joint analysis of Q sets of pvalues obtained for the same list of items. This joint analysis is performed by querying a composite hypothesis, i.e. an arbitrary complex combination of simple hypotheses, as described in MaryHuard et al. (2021) <doi:10.1093/bioinformatics/btab592> and De Walsche et al.(2023) <doi:10.1101/2024.03.17.585412>. In this approach, the Quplet of pvalues associated with each item is distributed as a multivariate mixture, where each of the 2^Q components corresponds to a specific combination of simple hypotheses. The dependence between the pvalue series is considered using a Gaussian copula function. A pvalue for the composite hypothesis test is derived from the posterior probabilities.
Package details 


Author  Tristan MaryHuard [aut, cre] (<https://orcid.org/0000000238399067>), Annaig De Walsche [aut] (<https://orcid.org/0000000306031716>), Franck Gauthier [ctb] (<https://orcid.org/000000030574065X>) 
Maintainer  Tristan MaryHuard <tristan.maryhuard@agroparistech.fr> 
License  GPL3 
Version  2.0.0 
Package repository  View on CRAN 
Installation 
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