ruv: Detect and Remove Unwanted Variation using Negative Controls

Implements the 'RUV' (Remove Unwanted Variation) algorithms. These algorithms attempt to adjust for systematic errors of unknown origin in high-dimensional data. The algorithms were originally developed for use with genomic data, especially microarray data, but may be useful with other types of high-dimensional data as well. These algorithms were proposed by Gagnon-Bartsch and Speed (2012), and by Gagnon-Bartsch, Jacob and Speed (2013). The algorithms require the user to specify a set of negative control variables, as described in the references. The algorithms included in this package are 'RUV-2', 'RUV-4', 'RUV-inv', and 'RUV-rinv', along with various supporting algorithms.

AuthorJohann Gagnon-Bartsch <johanngb@umich.edu>
Date of publication2015-07-18 17:00:34
MaintainerJohann Gagnon-Bartsch <johanngb@umich.edu>
LicenseGPL
Version0.9.6
http://www.stat.berkeley.edu/~johann/ruv

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