dot-rxDelaySensJumpMap: Dose-induced breaking-point jump for forward delay...
In rxode2: Facilities for Simulating from ODE-Based Models

.rxDelaySensJumpMap

R Documentation

Dose-induced breaking-point jump for forward delay sensitivities

Description

A dose propagated through delay(y_j, T(p)) makes the 1st-order sensitivity jump at t = t_dose + T by ⁠[S_i] = -(d f_i/d delay(y_j,T)) * [y_j] * dT/dp⁠, reproduced here as a modeled bolus of ⁠[y_j]⁠ on the sensitivity compartment with modeled lag T and bioavailability ⁠-(d f_i/d delay)*dT/dp⁠. .rxDelaySensJumpMap() does the model-only symengine analysis (cached via .rxDelaySensJumpMapCached()); .rxDelaySensJumpEvents() rbinds the mirroring doses per solve; .rxDelaySensJump() does both.

Usage

.rxDelaySensJumpMap(model, calcSens)

.rxDelaySensJumpEvents(jumpMap, st, events)

.rxDelaySensJump(model, calcSens, events)

.rxDelaySensJumpMapCached(model, calcSens, keyTxt = NULL)

Arguments

`model`	base ODE model (anything `rxNorm()` accepts).
`calcSens`	character vector of sensitivity parameters.
`jumpMap`	the jump map from `.rxDelaySensJumpMap()` (`⁠$jumpMap⁠`).
`st`	ODE state names (`⁠$st⁠` from `.rxDelaySensJumpMap()`), for numeric-cmt resolution.
`events`	an rxode2 event table (to mirror the state-j doses onto the sensitivity compartments).
`keyTxt`	normalized model text used as the cache key (pass `rxNorm(model)` if already computed, else it is derived).

Value

.rxDelaySensJumpMap(): list with alagf, jumpMap, and st, or NULL when the model has no parameter-dependent delay. .rxDelaySensJump(): list with alagf and events, or NULL.