seqmon: Group Sequential Design Class for Clinical Trials

S4 class object for creating and managing group sequential designs. It calculates the efficacy and futility boundaries at each look. It allows modifying the design and tracking the design update history.

Install the latest version of this package by entering the following in R:
AuthorDavid A Schoenfeld, PhD and Hui Zheng, PhD
Date of publication2016-10-12 00:43:08
Maintainer"Hui Zheng, PhD" <>
LicenseMIT + file LICENSE

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Man pages

alphaspend: Function that calculates the upper boundaries for efficacy

alphaspendf: The default alpha spending function

betaspend: Function that calculates the lower boundaries for futility

betaspendf: The default beta spending function

calcBoundaries: Function for calculating the efficacy and futility boundaries

calcBoundaries-methods: ~~ Methods for Function 'calcBoundaries' ~~

curtail: Generic function that calculates the probability to declare...

curtailDesign: Function for calculating the probability for efficacy given...

curtailDesign-methods: ~~ Methods for Function 'curtailDesign' ~~

getProbabilities: Function that calculates the cumulative probabilities to...

getProbabilities-methods: ~~ Methods for Function 'getProbabilities' ~~

plotBoundaries: Function that plots the efficacy and futility boundaries

plotBoundaries-methods: ~~ Methods for Function 'plotBoundaries' ~~

printSummary: Function that prints the cumulative probabilities for...

printSummary-methods: ~~ Methods for Function 'printSummary' ~~

seqmon: Generic function that calculates the cumulative alpha and...

seqmon-package: seqmon The sequential design class Class '""'

setAlphaspendfString: Function that Sets the expression of the base alpha spending...

setAlphaspendfString-methods: ~~ Methods for Function 'setAlphaspendfString' ~~

setBaseAlphaspendf: Function that sets the base alpha spending function

setBaseAlphaspendf-methods: ~~ Methods for Function 'setBaseAlphaspendf' ~~

setBaseBetaspendf: Function that sets the base beta spending function

setBaseBetaspendf-methods: ~~ Methods for Function 'setBaseBetaspendf' ~~

setBetaspendfString: Function that sets the expression of the base beta spending...

setBetaspendfString-methods: ~~ Methods for Function 'setBetaspendfString' ~~

setCurrentLook: Function that sets the current look number

setCurrentLook-methods: ~~ Methods for Function 'setCurrentLook' ~~

setDatestamp: Function that sets the date stamp of the design object

setDatestamp-methods: ~~ Methods for Function 'setDatestamp' ~~

setNoncentrality: Function that sets the noncentrality parameter

setNoncentrality-methods: ~~ Methods for Function 'setNoncentrality' ~~

setTimes: Function that sets the look times

setTimes-methods: ~~ Methods for Function 'setTimes' ~~

updateDesign: Function that updates the design

updateDesign-methods: ~~ Methods for Function 'updateDesign' ~~


alphaspend Man page
alphaspendf Man page
betaspend Man page
betaspendf Man page
calcBoundaries Man page
calcBoundaries, Man page
curtail Man page
curtailDesign Man page
curtailDesign-methods Man page
curtailDesign, Man page
getProbabilities Man page
getProbabilities-methods Man page
getProbabilities, Man page
plotBoundaries Man page
plotBoundaries-methods Man page
plotBoundaries, Man page
printSummary Man page
printSummary-methods Man page
printSummary, Man page
seqmon Man page
seqmon-package Man page Man page Man page, Man page
setAlphaspendfString Man page
setAlphaspendfString-methods Man page
setAlphaspendfString, Man page
setBaseAlphaspendf Man page
setBaseAlphaspendf-methods Man page
setBaseAlphaspendf, Man page
setBaseBetaspendf Man page
setBaseBetaspendf-methods Man page
setBaseBetaspendf, Man page
setBetaspendfString Man page
setBetaspendfString-methods Man page
setBetaspendfString, Man page
setCurrentLook Man page
setCurrentLook-methods Man page
setCurrentLook, Man page
setDatestamp Man page
setDatestamp-methods Man page
setDatestamp, Man page
setNoncentrality Man page
setNoncentrality-methods Man page
setNoncentrality, Man page
setTimes Man page
setTimes-methods Man page
setTimes, Man page
updateDesign Man page
updateDesign-methods Man page
updateDesign, Man page

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