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simIDM: Simulating Oncology Trials using an Illness-Death Model
Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.
Getting started
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Package details |
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| Author | Alexandra Erdmann [aut, cre], Kaspar Rufibach [aut], Holger Löwe [aut], Daniel Sabanés Bové [aut], F. Hoffmann-La Roche AG [cph, fnd], University of Ulm [cph, fnd] |
| Maintainer | Alexandra Erdmann <alexandra.erdmann@uni-ulm.de> |
| License | Apache License 2.0 |
| Version | 0.1.0 |
| URL | https://github.com/insightsengineering/simIDM/ |
| Package repository | View on CRAN |
| Installation |
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