Man pages for simIDM
Simulating Oncology Trials using an Illness-Death Model
| addStaggeredEntry | Staggered Study Entry |
| assert_intervals | Assertion for vector describing intervals |
| assert_positive_number | Assertion for Positive Number |
| avgHRExpOS | Average OS Hazard Ratio from Constant Transition Hazards |
| avgHRIntegExpOS | Helper Function for 'avgHRExpOS()' |
| censoringByNumberEvents | Event-driven censoring. |
| corPFSOS | Correlation of PFS and OS event times for data from the IDM |
| corTrans | Correlation of PFS and OS event times for Different... |
| empSignificant | Empirical Significance for a List of Simulated Trials |
| estimateParams | Estimate Parameters of the Multistate Model Using Clinical... |
| ExpHazOS | OS Hazard Function from Constant Transition Hazards |
| exponential_transition | Transition Hazards for Exponential Event Times |
| ExpQuantOS | Quantile function for OS survival function induced by an... |
| ExpSurvOS | OS Survival Function from Constant Transition Hazards |
| ExpSurvPFS | PFS Survival Function from Constant Transition Hazards |
| expvalOSInteg | Helper Function for Computing E(OS^2) |
| expvalPFSInteg | Helper Function for Computing E(PFS^2) |
| getCensoredData | Helper function for 'censoringByNumberEvents' |
| getClinicalTrials | Simulation of a Large Number of Oncology Clinical Trials |
| getDatasetWideFormat | Conversion of a Data Set from One Row per Transition to One... |
| getEventsAll | Number of recruited/censored/ongoing Patients. |
| getInit | Retrieve Initial Parameter Vectors for Likelihood... |
| getNumberEvents | Helper Function for 'trackEventsPerTrial' |
| getOneClinicalTrial | Simulation of a Single Oncology Clinical Trial |
| getOneToTwoRows | Transitions from the Intermediate State to the Absorbing... |
| getPCWDistr | Piecewise Exponentially Distributed Event Times |
| getPWCHazard | Piecewise Constant Hazard Values |
| getResults | Format Results of Parameter Estimation for Different... |
| getSimulatedData | Simulate Data Set from an Illness-Death Model |
| getSumPCW | Sum of Two Piecewise Constant Hazards |
| getTarget | Generate the Target Function for Optimization |
| getTimePoint | Time-point by which a specified number of events occurred. |
| getWaitTimeSum | Event Times Distributed as Sum of Weibull |
| haz | Hazard Function for Different Transition Models |
| integrateVector | Helper for Efficient Integration |
| log_p11 | Probability of Remaining in Progression Between Two Time... |
| logRankTest | Log-Rank Test for a Single Trial |
| negLogLik | Compute the Negative Log-Likelihood for a Given Data Set and... |
| p11Integ | Helper Function for 'log_p11()' |
| passedLogRank | Helper function to conduct log-rank tests for either PFS or... |
| PCWInversionMethod | Single Piecewise Exponentially Distributed Event Time |
| PFSOSInteg | Helper Function for 'survPFSOS()' |
| piecewise_exponential | Transition Hazards for Piecewise Exponential Event Times |
| prepareData | Preparation of a Data Set to Compute Log-likelihood |
| pwA | Cumulative Hazard for Piecewise Constant Hazards |
| PwcOSInt | Helper Function of 'PWCsurvOS()' |
| PWCsurvOS | OS Survival Function from Piecewise Constant Hazards |
| PWCsurvPFS | PFS Survival Function from Piecewise Constant Hazards |
| runTrial | Helper Function for Adding Progress Bar to Trial Simulation |
| simIDM-package | 'simIDM' Package |
| singleExpQuantOS | Helper Function for Single Quantile for OS Survival Function |
| survOS | OS Survival Function for Different Transition Models |
| survPFS | PFS Survival Function for Different Transition Models |
| survPFSOS | Survival Function of the Product PFS*OS for Different... |
| survTrans | Survival Function for Different Transition Models |
| trackEventsPerTrial | Event tracking in an oncology trial. |
| WeibOSInteg | Helper Function for 'WeibSurvOS()' |
| WeibSurvOS | OS Survival Function from Weibull Transition Hazards |
| WeibSurvPFS | PFS Survival Function from Weibull Transition Hazards |
| weibull_transition | Transition Hazards for Weibull Distributed Event Times |
