simdata_weibull: Simulate survival data for safety monitoring under Weibull...

In stoppingrule: Create and Evaluate Stopping Rules for Safety Monitoring

Simulate survival data for safety monitoring under Weibull distribution

Description

Internal function to simulate survival data from Weibull distribution for evaluating safety monitoring rules. A random sample of size n is generated from a Weibull distribution with shape parameter s to attain a toxicity rate of p at survival time tau. Enrollment times are also simulated over an accrual period of duration A under a uniform (0,A) distribution.

Usage

simdata_weibull(n, p, tau, A, s = 1)

Arguments

n	Maximum sample size for safety monitoring
p	The probability of a toxicity occurring in tau units of time under the null hypothesis
tau	Length of observation period
A	Length of accrual period
s	Shape parameter for the Weibull distribution; default value is 1 (exponential distribution)

Value

A matrix with two columns: patient enrollment time and event time

stoppingrule documentation built on April 12, 2025, 1:55 a.m.