template_fit_mmrm: Template: Mixed Model Repeated Measurements (MMRM) Analysis

In teal.modules.clinical: 'teal' Modules for Standard Clinical Outputs

Template: Mixed Model Repeated Measurements (MMRM) Analysis

Description

Creates a valid expression to generate analysis tables and plots for Mixed Model Repeated Measurements.

Usage

template_fit_mmrm(
  parentname,
  dataname,
  aval_var,
  arm_var,
  ref_arm,
  comp_arm = NULL,
  combine_comp_arms = FALSE,
  id_var,
  visit_var,
  cov_var,
  conf_level = 0.95,
  method = "Satterthwaite",
  cor_struct = "unstructured",
  weights_emmeans = "proportional",
  parallel = FALSE
)

template_mmrm_tables(
  parentname,
  dataname,
  fit_name,
  arm_var,
  ref_arm,
  visit_var,
  paramcd,
  show_relative = c("increase", "reduction", "none"),
  table_type = "t_mmrm_cov",
  total_label = default_total_label(),
  basic_table_args = teal.widgets::basic_table_args()
)

template_mmrm_plots(
  fit_name,
  lsmeans_plot = list(select = c("estimates", "contrasts"), width = 0.6, show_pval =
    FALSE),
  diagnostic_plot = list(type = "fit-residual", z_threshold = NULL),
  ggplot2_args = teal.widgets::ggplot2_args()
)

Arguments

parentname	(character) parent analysis data used in teal module, usually this refers to ADSL.
dataname	(character) analysis data used in teal module.
aval_var	(character) name of the analysis value variable.
arm_var	(character) variable names that can be used as arm_var.
ref_arm	(character) the level of reference arm in case of arm comparison.
comp_arm	(character) the level of comparison arm in case of arm comparison.
combine_comp_arms	(logical) triggers the combination of comparison arms.
id_var	(character) the variable name for subject id.
visit_var	(character) variable names that can be used as visit variable. Must be a factor in dataname.
cov_var	(character) names of the covariates variables.
conf_level	(numeric) value for the confidence level within the range of (0, 1).
method	(string) a string specifying the adjustment method.
cor_struct	(string) a string specifying the correlation structure, defaults to "unstructured". See tern.mmrm::build_formula() for more options.
weights_emmeans	argument from emmeans::emmeans(), "proportional" by default.
parallel	(flag) flag that controls whether optimizer search can use available free cores on the machine (not default).
fit_name	(string) name of fitted MMRM object.
paramcd	(character) name of the parameter code variable.
show_relative	(string) should the "reduction" (control - treatment, default) or the "increase" (treatment - control) be shown for the relative change from baseline.
table_type	(string) type of table to output.
total_label	(string) string to display as total column/row label if column/row is enabled (see add_total). Defaults to "All Patients". To set a new default total_label to apply in all modules, run set_default_total_label("new_default").
basic_table_args	(basic_table_args) optional object created by teal.widgets::basic_table_args() with settings for the module table. The argument is merged with option teal.basic_table_args and with default module arguments (hard coded in the module body). For more details, see the vignette: vignette("custom-basic-table-arguments", package = "teal.widgets").
lsmeans_plot	(named list) a list of controls for LS means plot. See more tern.mmrm::g_mmrm_lsmeans().
diagnostic_plot	(named list) a list of controls for diagnostic_plot. See more tern.mmrm::g_mmrm_diagnostic().
ggplot2_args	(ggplot2_args) optional object created by teal.widgets::ggplot2_args() with settings for the module plot. The argument is merged with option teal.ggplot2_args and with default module arguments (hard coded in the module body). For more details, see the vignette: vignette("custom-ggplot2-arguments", package = "teal.widgets").

Value

a list of expressions to generate a table or plot object.

Functions

• template_mmrm_tables(): Creates valid expressions to generate MMRM LS means, covariance matrix, fixed effects, and diagnostic tables.

• template_mmrm_plots(): Creates valid expressions to generate MMRM LS means and diagnostic plots.

See Also

tm_a_mmrm()

teal.modules.clinical documentation built on April 4, 2025, 12:35 a.m.