Tipping point analysis for clinical trials that employ Bayesian dynamic borrowing via robust metaanalytic predictive (MAP) priors. Mainly an implementation of an approach proposed by Best and colleagues (2021) is provided <doi:10.1002/pst.2093>. Further functions facilitate the specification of the robust MAP prior via expert elicitation (using the roulette method) and computation of the posterior distribution of the treatment effect with either fixed or stochastic expertelicited weights. Intended use is the planning, analysis and interpretation of extrapolation studies in pediatric drug development, but applicability is generally wider.
Package details 


Author  Morten Dreher [aut], Christian Stock [aut, cre] (<https://orcid.org/0000000234933234>), Emma Torrini [ctb] 
Maintainer  Christian Stock <christian.stock@boehringeringelheim.com> 
License  GPL (>= 3) 
Version  0.3.7 
Package repository  View on CRAN 
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