Nothing
# Rfun_psPwRtrigger
#
#' @name psPwRtrigger
#' @title Powers of testing the primary and secondary hypotheses using trigger strategy
#' @description This function computes the powers of testing the primary and secondary hypotheses using trigger strategy.
#' @param alpha a number shows the overall error rate
#' @param alpha0 a number shows the error rate assigned to the primary endpoint initially
#' @param t0 a vector shows the information times of the primary endpoint
#' @param t1 a vector shows the information times of the secondary endpoint
#' @param tc0 a vector shows the calendar times of the primary endpoint
#' @param tc1 a vector shows the calendar times of the secondary endpoint
#' @param rho a number shows the correlation between the primary and secondary endpoints
#' @param iuse0 an integer shows the type of group sequential boundaries used for the primary endpoint
#' @param iuse1 an integer shows the type of group sequential boundaries used for the secondary endpoint
#' @param phi0 a parameter for the power family or the HSD gamma family for the primary endpoint
#' @param phi1 a parameter for the power family or the HSD gamma family for the secondary endpoint
#' @param usingRhoForBoundary an indicator whether using the informaiton of rho to calculate the boundary, default is FALSE (not using)
#' @param groupsize a value of sample size in group 1
#' @param szratio a value of the sample size ratio, n2/n1
#' @param effsz0 a value of effect size for hypothesis H0
#' @param effsz1 a value of effect size for hypothesis H1
#' @return a vector of two values of the probability that H0 is rejected, and the probability that H1 is rejected, using the trigger strategy
#' @export
#' @examples
#' alpha <- 0.0250
#' alpha0 <- 0.0136
#' iuse0 <- 1
#' iuse1 <- 2
#' phi0 <- -4
#' phi1 <- 1
#' tc0 <- c(1,2)
#' tc1 <- c(1,2,3)
#' t0 <- c(0.6,1)
#' t1 <- c(0.5,0.9,1)
#' rho <- 0
#' effsz0 <- 0.33
#' effsz1 <- 0.30
#' groupsize=226
#' szratio=1
#' psPwRtrigger(alpha=alpha, alpha0=alpha0,
#' t0=t0, t1=t1, tc0=tc0, tc1=tc1,
#' rho=rho, iuse0=1, iuse1=iuse1,
#' phi0=phi0, phi1=phi1,
#' usingRhoForBoundary=FALSE,
#' groupsize=groupsize, szratio=szratio,
#' effsz0=effsz0, effsz1=effsz1)
#' @references
#' Gou, J. (2023). Trigger strategy in repeated tests on multiple hypotheses. \emph{Statistics in Biopharmaceutical Research}, 15(1), 133-140.
#' Gou, J. (2022). Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints. \emph{Biometrical Journal}, 64(2), 301-311.
#
psPwRtrigger <- function (alpha, alpha0, t0, t1, tc0=t0, tc1=t1, rho=0, iuse0=1, iuse1=1, phi0=rep(1,length(alpha)), phi1=rep(1,length(alpha)), usingRhoForBoundary=FALSE, groupsize, szratio=1, effsz0, effsz1) {
#
pspwr <- rep(0, times=2)
#
n1 <- groupsize
n2 <- szratio*groupsize
delta0 <- effsz0*sqrt(n1*n2/(n1+n2))
delta1 <- effsz1*sqrt(n1*n2/(n1+n2))
#
cvecList0 <- gbounds(t=t0, iuse=iuse0, alpha=alpha0, phi=phi0)
cvec0 <- cvecList0$bd
pspwr[1] <- marginalPwR(cvec=cvec0,t=t0,delta=delta0)
#
pspwr[2] <- sPwRtrigger(alpha=alpha, alpha0=alpha0, t0=t0, t1=t1, tc0=tc0, tc1=tc1, delta0=delta0, delta1=delta1, rho=rho, iuse0=iuse0, iuse1=iuse1, phi0=phi0, phi1=phi1, usingRhoForBoundary=usingRhoForBoundary)
#
return (pspwr)
}#
Any scripts or data that you put into this service are public.
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.