Simulated data for a hypothetical example

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Description

A simulated data set with 1000 informative case-parent trios to illustrate the trioGxE package.

Usage

1

Format

data frame with columns:

column name type details
[,1] parent 1 numeric copy number of the putative risk allele carried by the first parent (0, 1, 2)
[,2] parent 2 numeric copy number of the putative risk allele carried by the other parent (0, 1, 2)
[,3] child numeric copy number of the putative allele carried by the child (0, 1, 2)
[,4] subpop numeric membership for two subpopulations 0, 1
[,5] attr numeric non-genetic attribute value of the child

Note

The data contains 1000 informative case-parent trios, each of which has at least one heterozygous parent. The trios were generated, using trioSim under recessive quadratic gene-environment interaction, from a stratified population composed of two equal-sized subpopulations. The two subpopulations have different distributions for the SNP and the non-genetic attribute. For the SNP, the risk allele frequencies for the first (subpop=0) and second (subpop=1) subpopulations are 0.1 and 0.9, respectively. For the non-genetic attribute, the distributions in subpopulations 0 and 1 are Normal with subpopulation-specific means -0.8 and 0.8, respectively, and common variance 0.36.

See Also

trioSim