A simulated data set with 1000 informative case-parent trios to illustrate the
data frame with columns:
|[,1]||parent 1||numeric||copy number of the putative risk allele carried by the first parent (0, 1, 2)|
|[,2]||parent 2||numeric||copy number of the putative risk allele carried by the other parent (0, 1, 2)|
|[,3]||child||numeric||copy number of the putative allele carried by the child (0, 1, 2)|
|[,4]||subpop||numeric||membership for two subpopulations 0, 1|
|[,5]||attr||numeric||non-genetic attribute value of the child|
The data contains 1000 informative case-parent trios,
each of which has at least one heterozygous parent.
The trios were generated, using
under recessive quadratic gene-environment interaction,
from a stratified population composed of two equal-sized subpopulations.
The two subpopulations have different distributions for the SNP and the non-genetic attribute.
For the SNP, the risk allele frequencies for the first (
subpop=1) subpopulations are 0.1 and 0.9, respectively.
For the non-genetic attribute, the distributions in subpopulations 0 and 1 are Normal
with subpopulation-specific means -0.8 and 0.8, respectively, and common variance 0.36.