hypoTrioDat: Simulated data for a hypothetical example

In trioGxE: A data smoothing approach to explore and test gene-environment interaction in case-parent trio data

Description

A simulated data set with 1000 informative case-parent trios to illustrate the trioGxE package.

Usage

data(hypoTrioDat)

Format

data frame with columns:

	column name	type	details
[,1]	parent 1	numeric	copy number of the putative risk allele carried by the first parent (0, 1, 2)
[,2]	parent 2	numeric	copy number of the putative risk allele carried by the other parent (0, 1, 2)
[,3]	child	numeric	copy number of the putative allele carried by the child (0, 1, 2)
[,4]	subpop	numeric	membership for two subpopulations 0, 1
[,5]	attr	numeric	non-genetic attribute value of the child

Note

The data contains 1000 informative case-parent trios, each of which has at least one heterozygous parent. The trios were generated, using trioSim under recessive quadratic gene-environment interaction, from a stratified population composed of two equal-sized subpopulations. The two subpopulations have different distributions for the SNP and the non-genetic attribute. For the SNP, the risk allele frequencies for the first (subpop=0) and second (subpop=1) subpopulations are 0.1 and 0.9, respectively. For the non-genetic attribute, the distributions in subpopulations 0 and 1 are Normal with subpopulation-specific means -0.8 and 0.8, respectively, and common variance 0.36.

See Also

trioSim

trioGxE documentation built on May 2, 2019, 3:41 p.m.