est_overall: Estimate overall risk and vaccine efficacy

In vaccine: Statistical Tools for Immune Correlates Analysis of Vaccine Clinical Trial Data

Estimate overall risk and vaccine efficacy

Description

Estimate overall risk and vaccine efficacy.

Usage

est_overall(dat, t_0, method = "Cox", risk = TRUE, ve = TRUE)

Arguments

dat	A data object returned by load_data
t_0	Time point of interest
method	One of c("KM", "Cox"), corresponding to either a Kaplan-Meier estimator ("KM") or a marginalized Cox proportional hazards model ("Cox").
risk	Boolean. If TRUE, the controlled risk (CR) curve is computed.
ve	Boolean. If TRUE, the controlled vaccine efficacy (CVE) curve is computed.

Value

A dataframe containing estimates

Examples

data(hvtn505)
dat <- load_data(time="HIVwk28preunblfu", event="HIVwk28preunbl", vacc="trt",
                 marker="IgG_V2", covariates=c("age","BMI","bhvrisk"),
                 weights="wt", ph2="casecontrol", data=hvtn505)
est_overall(dat=dat, t_0=578, method="KM")

vaccine documentation built on April 4, 2025, 12:12 a.m.